Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The prevalence and determinants of freezing of gait among iranian patients with parkinson’s disease

Tue Dec 6 00:46:15 2022

(2020) The prevalence and determinants of freezing of gait among iranian patients with parkinson’s disease. Journal of Advances in Medical and Biomedical Research. pp. 138-143. ISSN 26766264 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Background & Objective: Freezing of gait (FOG) is accompanied by various complications, reduced quality of life, and increased risk of mortality and morbidity in patients with Parkinson’s disease. The incidence of this disabling phenomenon can be predicted in at least one-third of patients with Parkinson’s disease. Therefore, the current study aimed to investigate the prevalence of FOG among Iranian patients with Parkinson’s disease and to determine the predictors of this phenomenon in these patients. Materials & Methods: This cross-sectional study was performed on 135 patients with Parkinson’s disease, referred to Rasoul Akram Hospital, Tehran, Iran. The subjects were selected using the convenience sampling method. FOG was confirmed via clinical examination by two fellows of the movement disorder fellowship program. Variables were evaluated using bivariate and multivariate logistic regression analyses, receiver operating characteristics (ROC) curve analysis, and measurement of the area under the ROC curve (AUC). Results: Out of 135 patients with Parkinson’s disease, 36 (26.7) had FOG. Based on the results, FOG had a significantly higher prevalence in older patients, compared to younger patients. According to the results, FOG had no significant relationship with other baseline variables, including gender, disease duration, and disease manifestations. According to the multivariate logistic regression model, advanced age (OR: 0.915; P=0.031) and longer disease duration (OR: 0.992; P=0.019) predicted the incidence of FOG in the presence of underlying factors. Conclusion: The prevalence of FOG among patients with Parkinson’s disease was estimated at 26.7, which is within the global range. The results revealed that age and duration of disease were two factors, which could predict the occurrence of FOG with high sensitivity and specificity. © 2020.

Item Type: Article
Creators:
CreatorsEmail
Habibi, S. A. H.UNSPECIFIED
Rahmani, S. S.UNSPECIFIED
Goudarzi, S.UNSPECIFIED
Rohani, M.UNSPECIFIED
Shahidi, G.UNSPECIFIED
Farazmand, B.UNSPECIFIED
Vosough, F.UNSPECIFIED
Vosough, F.UNSPECIFIED
Modara, F.UNSPECIFIED
Mahdizadeh, F.UNSPECIFIED
Keywords: Freezing of Gait Parkinson's disease Prevalence Risk Factors adult Article bradykinesia controlled study cross-sectional study diagnostic test accuracy study disease duration disease severity dyskinesia female human Iranian (citizen) major clinical study male motor dysfunction Parkinson disease receiver operating characteristic sensitivity and specificity Unified Parkinson Disease Rating Scale
Divisions:
Page Range: pp. 138-143
Journal or Publication Title: Journal of Advances in Medical and Biomedical Research
Journal Index: Scopus
Volume: 28
Number: 128
Identification Number: https://doi.org/10.30699/jambs.28.128.124
ISSN: 26766264 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3165

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