Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The prevalence of human bocavirus in <2-year-old children with acute bronchiolitis

Fri May 24 10:56:26 2024

(2020) The prevalence of human bocavirus in <2-year-old children with acute bronchiolitis. New Microbes and New Infections. ISSN 20522975 (ISSN)

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Acute bronchiolitis is one of the most common lower respiratory tract infections in children with less than 2 years of age. Nowadays, molecular methods provide an opportunity to better understand the etiology of bronchiolitis. Several viral agents including Respiratory syncytial virus (RSV), Rhinovirus, Parainfluenza and Human bocavirus (HBoV) are responsible for acute bronchiolitis. There are growing studies on the prevalence of HBoV in patients with bronchiolitis. The present systematic review and meta-analysis were conducted to determine the pooled prevalence of HBoV in the respiratory samples of children with acute bronchiolitis. A literature search was conducted in the databases of PubMed, Scopus and Web of Science to recruit studies reporting the frequency of HBoV in <2-year-old children with acute bronchiolitis from 2005 to 2019. Only studies that used polymerase chain reaction (PCR)-based methods to detect the virus in nasopharyngeal samples were included. A total of 22 studies assessing 6751 cases were analyzed. According to the meta-analysis based on the random-effects model, the overall prevalence of HBoV in children with <2 years old was obtained 13 (95 CI: 0.09-0.17). Additionally, the rates of single (as the sole organism) and mixed (in combination with other viruses) HBoV infections were 4 and 9, respectively. This study showed a high rate of HBoV detection in children with acute bronchiolitis. This should be considered as part of a diagnostic test panel for respiratory infections in children with bronchiolitis. © 2020 The Authors

Item Type: Article
Keywords: Bronchiolitis Children Human bocavirus (HBoV) Prevalence Respiratory virus Bocavirus infection diagnostic test human Human bocavirus meta analysis nasopharyngeal aspiration polymerase chain reaction priority journal Review risk factor systematic review
Journal or Publication Title: New Microbes and New Infections
Journal Index: Scopus
Volume: 37
Identification Number:
ISSN: 20522975 (ISSN)
Depositing User: مهندس مهدی شریفی

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