Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

HSV-TK Expressing Mesenchymal Stem Cells Exert Inhibitory Effect on Cervical Cancer Model

Fri Jun 21 22:15:43 2024

(2020) HSV-TK Expressing Mesenchymal Stem Cells Exert Inhibitory Effect on Cervical Cancer Model. International journal of molecular and cellular medicine. pp. 146-154. ISSN 2251-9637 (Print) 2251-9637 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/32934952

Abstract

A growing area of research is focused on cancer therapy, and new therapeutic approaches are welcomed. Mesenchymal stem cell (MSC)-based gene therapy is a promising strategy in oncology. Intrinsic tropism and migration to tumor microenvironment with off lights are attractive features of this type of cell carrier. In this way, suicide genes have also found a good platform for better performance and have shown a stronger anti-tumor mechanism by riding on mesenchymal cells. In this study, we investigated the anti-tumor activity of intratumoral injected MSCs transduced with a lentivector expressing the HSV/TK in a mouse cervical cancer model. Following the injection of MSCs transduced with lentivector carrying TK, MSCs alone or PBS into the mice tumor, ganciclovir was administered intraperitoneally during 14 days, and tumor size, survival time, natural killer (NK) cells and cytotoxic T lymphocyte (CTL) activities were assessed. We demonstrated that combination of suicide therapy and cell therapy leading m,to successful tumor inhibition. Significant reduction in tumor size was detected in test group in comparison with controls. Also, potent antitumor NK and CTL activity was seen in treatment group in comparison with controls. Our data demonstrated that the mesenchymal cells expressing TK had inhibitory effect on cervical cancer model.

Item Type: Article
Creators:
CreatorsEmail
Kenarkoohi, A.UNSPECIFIED
Bamdad, T.UNSPECIFIED
Soleimani, M.UNSPECIFIED
Soleimanjahi, H.UNSPECIFIED
Fallah, A.UNSPECIFIED
Falahi, S.UNSPECIFIED
Keywords: Cervical cancer cell therapy lentivector mesenchymal stem cell suicide therapy thymidine kinase
Divisions:
Page Range: pp. 146-154
Journal or Publication Title: International journal of molecular and cellular medicine
Journal Index: Pubmed
Volume: 9
Number: 2
Identification Number: https://doi.org/10.22088/IJMCM.BUMS.9.2.146
ISSN: 2251-9637 (Print) 2251-9637 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3101

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