Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Stem cell transplantation and functional recovery after spinal cord injury: a systematic review and meta-analysis

Fri Jul 1 21:54:11 2022

(2018) Stem cell transplantation and functional recovery after spinal cord injury: a systematic review and meta-analysis. Anatomy & Cell Biology. pp. 180-188. ISSN 2093-3665

Full text not available from this repository.

Official URL: http://apps.webofknowledge.com/InboundService.do?F...

Abstract

Spinal cord injury is a significant cause of motor dysfunctions. There is no definite cure for it, and most of the therapeutic modalities are only symptomatic treatment. In this systematic review and meta-analysis, the effectiveness of stem cell therapy in the treatment of the spinal cord injuries in animal models was studied and evaluated. A systematic search through medical databases by using appropriate keywords was conducted. The relevant reports were reviewed in order to find out cases in which inclusion and exclusion criteria had been fulfilled. Finally, 89 articles have been considered, from which 28 had sufficient data for performing statistical analyses. The findings showed a significant improvement in motor functions after cell therapy. The outcome was strongly related to the number of transplanted cells, site of injury, chronicity of the injury, type of the damage, and the induction of immune-suppression. According to our data, improvements in functional recovery after stem cell therapy in the treatment of spinal cord injury in animal models was noticeable, but its outcome is strongly related to the site of injury, number of transplanted cells, and type of transplanted cells.

Item Type: Article
Creators:
CreatorsEmail
Abbaszadeh, H. A.UNSPECIFIED
Niknazar, S.UNSPECIFIED
Darabi, S.UNSPECIFIED
Roozbahany, N. A.UNSPECIFIED
Noori-Zadeh, A.UNSPECIFIED
Ghoreishi, S. K.UNSPECIFIED
Khoramgah, M. S.UNSPECIFIED
Sadeghi, Y.UNSPECIFIED
Keywords: Stem cell therapy Spinal cord injuries Meta-analysis Contusions oligodendrocyte-like cells neural stem/progenitor cells marrow stromal cells rat model contusion model schwann-cells mouse model repair growth triiodothyronine Anatomy & Morphology
Divisions:
Page Range: pp. 180-188
Journal or Publication Title: Anatomy & Cell Biology
Journal Index: ISI
Volume: 51
Number: 3
Identification Number: https://doi.org/10.5115/acb.2018.51.3.180
ISSN: 2093-3665
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/31

Actions (login required)

View Item View Item