Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

In situ decorated Au NPs on pectin-modified Fe3O4 NPs as a novel magnetic nanocomposite (Fe3O4/Pectin/Au) for catalytic reduction of nitroarenes and investigation of its anti-human lung cancer activities

Tue Jul 23 20:35:27 2024

(2020) In situ decorated Au NPs on pectin-modified Fe3O4 NPs as a novel magnetic nanocomposite (Fe3O4/Pectin/Au) for catalytic reduction of nitroarenes and investigation of its anti-human lung cancer activities. International Journal of Biological Macromolecules. ISSN 1879-0003 (Electronic) 0141-8130 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/32961190

Abstract

In recent days, the green synthesized nanomagnetic biocomposites have been evolved with tremendous potential as the future catalysts. This has encouraged us to design and synthesis of a novel Au NPs immobilized pectin modified magnetic nanoparticles (Fe3O4/Pectin/Au). It was meticulously characterized using advanced analytical techniques like FT-IR, FESEM, TEM, EDX, XPS, VSM, XRD and ICP-OES. We investigated the chemical applications of the material in the catalytic reduction of nitroarenes using N2H4.H2O as the reducing agent in the EtOH/H2O solvent without any promoters or ligands. Due to strong paramagnetism, the catalyst was easily recovered and reused in 11cycles without considerable leaching or loss in reactivity. The green protocol involves several advantages like mild conditions, easy workup, high yields, and reusability of the catalyst. Furthermore, the desired nanocomposite was employed in biological studies like anti-oxidant assay by DPPH radical scavenging test. Subsequently, on exhibiting a good IC50 value in the DPPH assay, we extended the bio-application of the Fe3O4/Pectin/Au in the anticancer study of adenocarcinoma cells of human lungs using three cancer cell lines, PC-14, LC-2/ad and HLC-1 and a normal cell line HUVEC. The best result was accomplished in PC-14 cell lines with the lowest IC50 values.

Item Type: Article
Creators:
CreatorsEmail
Li, Y.UNSPECIFIED
Li, N.UNSPECIFIED
Jiang, W.UNSPECIFIED
Ma, G.UNSPECIFIED
Zangeneh, M. M.UNSPECIFIED
Keywords: Adenocarcinoma Fe(3)O(4)/Pectin/Au Human lung cancer Nitroarenes Reduction Reusable competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Divisions:
Journal or Publication Title: International Journal of Biological Macromolecules
Journal Index: Pubmed
Identification Number: https://doi.org/10.1016/j.ijbiomac.2020.09.102
ISSN: 1879-0003 (Electronic) 0141-8130 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3098

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