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Ilam University of Medical Sciences

A historical review of the role of cytokines involved in leishmaniasis

Mon Apr 15 07:15:08 2024

(2020) A historical review of the role of cytokines involved in leishmaniasis. Cytokine. p. 155297. ISSN 1096-0023 (Electronic) 1043-4666 (Linking)

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Leishmaniasis is an infectious disease caused by the Leishmania genus, affecting millions of persons in the world. Despite increased studies, no vaccine has been developed against leishmaniasis, and drug resistance is evolving in some Leishmania species (spp). Innate and acquired immune cells and their associated cytokines interplay together to determine the immune responses related outcomes in leishmaniasis. Interferon (IFN)-gamma or macrophage activating factor (MAF) is the first effective lymphokine (LK), with a related function to leishmaniasis, discovered in 1979. This review article discussed the history of cytokines involved in Leishmania infection, and it is the first report demonstrating the involvement in the disease by focusing on cutaneous leishmaniasis. Up to now, the role of many cytokines has been determined and the literature review showed that IL-35 is the latest known cytokine involved in leishmaniasis. This review revealed that the cytokines have pleiotropic effects, depending upon the cytokine environment, generated during the infection and the host genetic background or infecting Leishmania spp. Overall, advances in our knowledge of immune cells and their secreted cytokines, contributing to the protection or pathological process of leishmaniasis may help to reach new approaches for immunotherapy.

Item Type: Article
Keywords: Cytokine Immune response Leishmania Leishmaniasis Polymorphism competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Page Range: p. 155297
Journal or Publication Title: Cytokine
Journal Index: Pubmed
Identification Number:
ISSN: 1096-0023 (Electronic) 1043-4666 (Linking)
Depositing User: مهندس مهدی شریفی

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