Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Does exercise training attenuate cisplatin nephrotoxicity?

Tue Jul 23 23:56:43 2024

(2020) Does exercise training attenuate cisplatin nephrotoxicity? Journal of Renal Injury Prevention. p. 4. ISSN 2345-2781

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Cisplatin (CP), a medication originating from the platinum has been used for solid cancers' treatment in the last decade. CP is associated with numerous side effects as well. One of the side effects is nephrotoxicity. There are some types of procedure which can attenuate harmful effects of the drug, and the effectiveness of physical activity has been a controversial topic. It is well established that physical activity has positive effects on chronic kidney disease (CKD). The exercise training can modulate CP induced muscle wasting both in males and females. Although exercise training may have protective effect on renal function and the related risk factors, it cannot attenuate the renal injury resulted from CP therapy in females. The exercise training may improve interleukin 6 and heme oxygenase-1, reduces the production of CD4+T cell cytokines from the kidney, which play a major role in adaptive immune response. The present mini-review considered the effect of exercise training accompanied by the CP treatment.

Item Type: Article
Kaffashian, M. R.UNSPECIFIED
Nematbakhsh, M.UNSPECIFIED
Keywords: Aerobic training Acute kidney injury Nephrotoxicity Cisplatin chronic kidney-disease estimated gfr mechanisms adults Urology & Nephrology
Page Range: p. 4
Journal or Publication Title: Journal of Renal Injury Prevention
Journal Index: ISI
Volume: 9
Number: 4
Identification Number:
ISSN: 2345-2781
Depositing User: مهندس مهدی شریفی

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