Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The increasing antimicrobial resistance ofHelicobacter pyloriin Iran: A systematic review and meta-analysis

Mon Sep 26 21:44:09 2022

(2020) The increasing antimicrobial resistance ofHelicobacter pyloriin Iran: A systematic review and meta-analysis. Helicobacter. p. 11. ISSN 1083-4389

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Abstract

Background Antimicrobial resistance ofHelicobacter pylorican result in eradication failure. Metadata on the antimicrobial resistance ofH pyloriin Iran could help to formulateH pylorieradication strategies in Iran. Methods A systematic review was performed after searching in MEDLINE, Scopus, Embase, Web of Science, and the Cochrane Library. A meta-analysis was performed, and a comparison of the rates between children and adults; time periods (1999-2010, 2011-2016, 2017-2019); and the methods used was carried out. Results A total of 66 studies investigating 5936H pyloriisolates were analyzed. The weighted pooled resistance (WPR) rates were as follows: clarithromycin 21 (95 CI 16-26), metronidazole 62 (95 57-67), clarithromycin in combination with metronidazole 16 (95 CI 10-23), ciprofloxacin 24 (95 CI 15-33), levofloxacin 18 (95 CI 9-30), erythromycin 29 (95 CI 12-50), furazolidone 13 (95 CI 4-27), tetracycline 8 (95 CI 5-13), and amoxicillin 15 (95 CI 9-22). During the three time periods, there was an increased resistance to amoxicillin, clarithromycin, ciprofloxacin, furazolidone, and tetracycline (P < .05). Furazolidone and a clarithromycin/metronidazole combination had the higher resistance rates in children (P < .05). Conclusion An increasing rate of resistance to amoxicillin, clarithromycin, ciprofloxacin, furazolidone, and tetracycline in IranianH pyloriisolates was identified. In children, the resistance to furazolidone and a combination of clarithromycin and metronidazole is higher compared to adults. As a stable, high resistance to metronidazole was found in children and adults in all Iranian provinces, we suggest that metronidazole should not be included in the IranianH pylorieradication scheme.

Item Type: Article
Creators:
CreatorsEmail
Sholeh, M.UNSPECIFIED
Maleki, F.UNSPECIFIED
Krutova, M.UNSPECIFIED
Bavari, S.UNSPECIFIED
Golmoradi, R.UNSPECIFIED
Sadeghifard, N.UNSPECIFIED
Amiriani, T.UNSPECIFIED
Kouhsari, E.UNSPECIFIED
Keywords: Antimicrobial resistance Helicobacter pylori Iran Systematic Review and Meta-analysis helicobacter-pylori antibiotic-resistance clarithromycin resistance metronidazole resistance high-frequency ribosomal-rna strains eradication mutations tetracycline Gastroenterology & Hepatology Microbiology
Divisions:
Page Range: p. 11
Journal or Publication Title: Helicobacter
Journal Index: ISI
Identification Number: https://doi.org/10.1111/hel.12730
ISSN: 1083-4389
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3052

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