Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

A Review on the Relation between Sepsis and Vitamin D Level among Neonatal Intensive Care Unit Infants

Mon Oct 3 00:00:12 2022

(2020) A Review on the Relation between Sepsis and Vitamin D Level among Neonatal Intensive Care Unit Infants. International Journal of Pediatrics-Mashhad. pp. 11849-11854. ISSN 2345-5047

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Abstract

Background Neonatal sepsis is a critical condition caused by a generalized bacterial infection in the first month of life. The present study aimed to investigate the relationship between serum vitamin D levels and neonatal sepsis. Materials and Methods: A search of online databases (Medline, Cochrane Library, Web of Science, EMBASE-Ovid, and Scopus) were carried out for randomized control trials and non-randomized prospective or retrospective clinical studies published in English till April 2020. Two reviewers selected the studies. Results: In the first study, the level of 25-hydroxyvitamin D 25(OH)D in the cord-blood sample of infants in the Early-Onset Neonatal Sepsis (EONS) group was significantly lower compared to the control group. 25(OH)D level (19 ng/ml) in the control group were significantly higher compared to the 25(OH) level (8.6 ng/ml) in the sepsis group. In the third study, the serum 25(OH) level showed a significant decrease in the affected neonates (6.4 nmol/L) compared to healthy neonates (42.5 nmol/L). In the fourth study, the sepsis and control group had a significant difference in the level of 25(OH)D (69 +/- 7.5ng/ml and 35 +/- 19ng/ml). According to the fifth study, the serum 25(OH)D level was insufficient in the case group and sufficient in the control group (p<0.0001). In the sixth study, the odds of very-early-onset neonatal sepsis among the neonates who had the serum 25-hydroxyvitamin D deficiency were lower compared to the odds among neonates who did not have serum 25-hydroxyvitamin D deficiency. Conclusion The level of 25-hydroxyvitamin D in the blood sample of infants in the sepsis group was significantly lower compared to the control group; further studies required to confirm the results by considering more confounders.

Item Type: Article
Creators:
CreatorsEmail
Mameneh, M.UNSPECIFIED
Akhlagh, S. A.UNSPECIFIED
Sharifi, P.UNSPECIFIED
Fekri, S. D.UNSPECIFIED
Khorasani, F.UNSPECIFIED
Asadi, N.UNSPECIFIED
Ashrafinia, F.UNSPECIFIED
Safavi, S.UNSPECIFIED
Keywords: Infants Sepsis Neonatal Intensive Care Unit Vitamin D d deficiency risk Pediatrics
Divisions:
Page Range: pp. 11849-11854
Journal or Publication Title: International Journal of Pediatrics-Mashhad
Journal Index: ISI
Volume: 8
Number: 8
Identification Number: https://doi.org/10.22038/ijp.2020.50299.4001
ISSN: 2345-5047
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3049

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