Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Introducing a novel nanocomposite consisting of nitrogen-doped carbon nano-onions and gold nanoparticles for the electrochemical sensor to measure acetaminophen

Sat Oct 1 12:55:54 2022

(2020) Introducing a novel nanocomposite consisting of nitrogen-doped carbon nano-onions and gold nanoparticles for the electrochemical sensor to measure acetaminophen. Journal of Electroanalytical Chemistry. p. 11. ISSN 1572-6657

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Abstract

In the present study, gold nanoparticles and nitrogen-doped carbon nano-onions (AuNP/NCNO) in a nanocomposite-based sensor were reported for the electrochemical detection of acetaminophen (APAP). The NCNOs from the fullerene family were prepared using a simple and cost-effective method using aminated nanodiamonds (AM-ND) as a substrate. Nitrogen atoms were introduced into CNO cages during the preparation of these nanostructures by annealing AM-NDs under an inert helium atmosphere and reduced pressure. AuNPs were synthesized using a straightforward method. The nanocomposite profoundly enhanced the active surface area of the glassy carbon electrode and amplified the electron transfer rate. Accordingly, electrocatalysis of the APAP was achieved at the modified electrode surface at 0.38 V vs. Ag/AgCl. Under the optimal conditions, the sensor displayed a linear response for APAP detection ranging from 25 nM to 35 mu M with a limit of detection (LOD) of 9 nM. Potentially interfering drugs, such as ascorbic acid and dopamine, with 5-fold higher concentrations did not interfere with APAP detection. The feasibility of the sensor for APAP detection in tablet and serum samples was successfully evaluated. The qualities of this sensor, including its rapid-response, sensitivity and ease of use, maybe beneficial for potential applications in detecting other drugs.

Item Type: Article
Creators:
CreatorsEmail
Sohouli, E.UNSPECIFIED
Shahdost-Fard, F.UNSPECIFIED
Rahimi-Nasrabadi, M.UNSPECIFIED
Plonska-Brzezinska, M. E.UNSPECIFIED
Ahmadi, F.UNSPECIFIED
Keywords: Nitrogen-doped carbon Nano-onion Gold nanoparticle Acetaminophen Electrocatalysis Voltammetric detection facile synthesis composite graphene nanomaterials reduction nanotubes electrode Chemistry Electrochemistry
Divisions:
Page Range: p. 11
Journal or Publication Title: Journal of Electroanalytical Chemistry
Journal Index: ISI
Volume: 871
Identification Number: https://doi.org/10.1016/j.jelechem.2020.114309
ISSN: 1572-6657
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3047

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