Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Current situation and future prospects ofEchinococcus granulosusvaccine candidates: A systematic review

Mon Sep 26 13:12:35 2022

(2020) Current situation and future prospects ofEchinococcus granulosusvaccine candidates: A systematic review. Transboundary and Emerging Diseases. p. 17. ISSN 1865-1674

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Abstract

Cystic echinococcosis is a worldwide zoonotic disease, represents a threat for livestock and humans, manifests as a quiescent, subclinical and chronic hydatid cyst infection. The disease imposes high expenditures and economic losses in medical and veterinary. Prophylactic vaccination would be one of the effective preventive health care against echinococcosis. During the last decades, many studies have characterized the protective antigens ofEchinococcus granulosusand their role in immunization of various animal host species. Herein, we aimed to systematically evaluate and represent the best antigens as possible vaccine candidates for cystic echinococcosis. Data were systematically searched from five databases including ProQuest, PubMed, Scopus, ScienceDirect and Web of Science, up to 1 February 2020. Two reviewers independently screened and assessed data extraction and quality assessment. A total of 47 articles were eligible for inclusion criteria in the current study. The most common antigens used for vaccination againstE. granulosuswere EG95 and antigen B. Freund's adjuvant and Quil A have been predominantly utilized. In addition, regarding the antigen delivery, animal models, measurement of immune responses and reduction in hydatid cyst have been discussed in the text. The data demonstrated that DNA vaccines with antigen B and recombinant protein vaccines based on EG95 antigen have the best results and elicited protective immune responses.

Item Type: Article
Creators:
CreatorsEmail
Anvari, D.UNSPECIFIED
Rezaei, F.UNSPECIFIED
Ashouri, A.UNSPECIFIED
Rezaei, S.UNSPECIFIED
Majidiani, H.UNSPECIFIED
Pagheh, A. S.UNSPECIFIED
Shariatzadeh, S. A.UNSPECIFIED
Fotovati, A.UNSPECIFIED
Siyadatpanah, A.UNSPECIFIED
Gholami, S.UNSPECIFIED
Ahmadpour, E.UNSPECIFIED
Keywords: DNA vaccine Echinococcosis Hydatid cyst Immunization Protein vaccine ovine cystic echinococcosis host-protective antigen eg95 hydatid vaccine pilot field trial antibody-responses taenia-hydatigena immune-response DNA vaccines rio negro mice Infectious Diseases Veterinary Sciences
Divisions:
Page Range: p. 17
Journal or Publication Title: Transboundary and Emerging Diseases
Journal Index: ISI
Identification Number: https://doi.org/10.1111/tbed.13772
ISSN: 1865-1674
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3046

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