Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Serum vascular endothelial growth factor (VEGF) levels in ischemic stroke patients: a systematic review and meta-analysis of case-control studies

Tue Oct 4 00:52:53 2022

(2020) Serum vascular endothelial growth factor (VEGF) levels in ischemic stroke patients: a systematic review and meta-analysis of case-control studies. Neurological Sciences. p. 10. ISSN 1590-1874

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Abstract

Serum VEGF level is regarded to be a biomarker for the diagnosis of stroke. Even though there have been published plethora of original articles describing higher blood VEGF concentrations since the 1970s, however, there is no any meta-analysis report for serum VEGF levels in the field of evidence-based medicine yet. A systematic review was performed by searching the online biomedical databases including retrieving 14 case-control studies including within-article subgroups after fulfilling the inclusion and exclusion criteria without the beginning date restriction, until 2020 for ischemic stroke patients. The Q quantity andI(2) statistic index showed a high heterogeneity (84.895 and 84.687, respectively) and the random-effects model of meta-analysis was applied for further analyses. The meta-analysis on a total number of 769 stroke subjects and 621 controls found that the weighted pooled SMD for overall serum VEGF levels on different days of testing was 1.92 (95 CI, - 4.059-0.219,pvalue = 0.079) and the pooled SMD for overall serum VEGF levels on day 1 of testing was - 1.083 (95 CI, - 4.229-2.063,pvalue = 0.500). The meta-regression results demonstrated that different days of testing do not significantly affect serum VEGF concentrations in ischemic patients and actually their serum levels are time-independent. Based on the recently published studies, this meta-analysis showed that serum VEGF levels were not significantly associated with an ischemic stroke diagnosis. Thus, researchers may concern another ideal serum or cerebrospinal fluid-derived biomarker for stroke diagnosis.

Item Type: Article
Creators:
CreatorsEmail
Seidkhani-Nahal, A.UNSPECIFIED
Khosravi, A.UNSPECIFIED
Mirzaei, A.UNSPECIFIED
Basati, G.UNSPECIFIED
Abbasi, M.UNSPECIFIED
Noori-Zadeh, A.UNSPECIFIED
Keywords: Serum biomarker Meta-analysis VEGF Ischemic stroke Hemorrhagic stroke Neurosciences & Neurology
Divisions:
Page Range: p. 10
Journal or Publication Title: Neurological Sciences
Journal Index: ISI
Identification Number: https://doi.org/10.1007/s10072-020-04698-7
ISSN: 1590-1874
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3042

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