Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Fabrication of Pd NPs on pectin-modified Fe3O4 NPs: A magnetically retrievable nanocatalyst for efficient C-C and C-N cross coupling reactions and an investigation of its cardiovascular protective effects

Sat Dec 10 02:31:41 2022

(2020) Fabrication of Pd NPs on pectin-modified Fe3O4 NPs: A magnetically retrievable nanocatalyst for efficient C-C and C-N cross coupling reactions and an investigation of its cardiovascular protective effects. International Journal of Biological Macromolecules. pp. 1252-1262. ISSN 0141-8130

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Abstract

The present report represents the synthesis of a novel Pd NPs immobilized over a natural polysaccharide (pectin) coated Fe3O4 magnetic nanocomposite material (Fe3O4@pectin/Pd) for investigating the cardiovascular protective effects. The biomolecular functionalization not only stabilizes the ferrite nanoparticles from agglomeration but also provides an environment for the biogenic reduction of Pd2+ ions. This protocol is a promising breakthrough for the synthesis of a quasi-heterogeneous catalyst, a bridge between heterogeneous and homogeneous medium. The structure, morphology and physicochemical properties of the material were characterized utilizing various analytical techniques like FT-IR FE-SEM, TEM, VSM, EDX-elemental mapping, ICP, EDX and XPS. The catalyst showed excellent reactivity in C-C and C-N cross coupling reactions via Suzuki and Buchwald-Hartwig reactions respectively. An array of different biphenyls and aryl amines were then procured by reactions of various aryl halides with phenyl boronic acid or secondary amines over the catalyst affording good to excellent yields. The catalyst was easily recoverable using an external magnet and thereafter recycled for several trials with insignificant palladium leaching or loss in catalytic performance. To investigate the cardiovascular protective activities of catalyst, the MTT assay was done on Human Aortic Endothelial Cells (HAEC), Human Coronary Artery Endothelial Cells (HCAEC), and Human Pulmonary Artery Endothelial Cells (HPAEC) cell lines. Nanocatalyst-treated cell cutlers significantly (p <= 0.01) decreased the caspase-3 activity, and DNA fragmentation. It raised the cell viability and mitochondrial membrane potential in the high concentration of Mitoxantrone-treated HAEC, HCAEC, and HPAEC cells. According to the above findings, nanocatalyst can be administrated as a cardiovascular protective drug for the treatment of cardiovascular diseases after approving in the clinical trial studies in humans. (C) 2020 Published by Elsevier B.V.

Item Type: Article
Creators:
CreatorsEmail
Zhang, W.UNSPECIFIED
Veisi, H.UNSPECIFIED
Sharifi, R.UNSPECIFIED
Salamat, D.UNSPECIFIED
Karmakar, B.UNSPECIFIED
Hekmati, M.UNSPECIFIED
Hemmati, S.UNSPECIFIED
Zangeneh, M. M.UNSPECIFIED
Zhang, Z. Y.UNSPECIFIED
Su, Q.UNSPECIFIED
Keywords: Nanocatalyst Pd NPs Pectin-modified Fe3O4 NPs Cardiovascular protective drug Mitoxantrone Cell death supported palladium catalyst highly-active catalyst canina fruit extract suzuki-miyaura heterogeneous catalyst recyclable nanocatalyst silver nanoparticles aryl chlorides heck complexes Biochemistry & Molecular Biology Chemistry Polymer Science
Divisions:
Page Range: pp. 1252-1262
Journal or Publication Title: International Journal of Biological Macromolecules
Journal Index: ISI
Volume: 160
Identification Number: https://doi.org/10.1016/j.ijbiomac.2020.05.247
ISSN: 0141-8130
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3040

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