Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The use of proteomics for the identification of promising vaccine and diagnostic biomarkers in Plasmodium falciparum

Thu Oct 6 07:38:40 2022

(2020) The use of proteomics for the identification of promising vaccine and diagnostic biomarkers in Plasmodium falciparum. Parasitology. pp. 1255-1262. ISSN 0031-1820

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Abstract

Plasmodium falciparumis the main cause of severe malaria in humans that can lead to death. There is growing evidence of drug-resistance inP. falciparumtreatment, and the design of effective vaccines remains an ongoing strategy to control the disease. On the other hand, the recognition of specific diagnostic markers forP. falciparumcan accelerate the diagnosis of this parasite in the early stages of infection. Therefore, the identification of novel antigenic proteins especially by proteomic tools is urgent for vaccination and diagnosis ofP. falciparum. The proteome diversity of the life cycle stages ofP. falciparum, the altered proteome ofP. falciparum-infected human sera and altered proteins inP. falciparum-infected erythrocytes could be proposed as appropriate proteins for the aforementioned aims. Accordingly, this review highlights and proposes different proteins identified using proteomic approaches as promising markers in the diagnosis and vaccination ofP. falciparum.It seems that most of the candidates identified in this study were able to elicit immune responses in theP. falciparum-infected hosts and they also played major roles in the life cycle, pathogenicity and key pathways of this parasite.

Item Type: Article
Creators:
CreatorsEmail
Mansouri, R.UNSPECIFIED
Ali-Hassanzadeh, M.UNSPECIFIED
Shafiei, R.UNSPECIFIED
Savardashtaki, A.UNSPECIFIED
Karimazar, M.UNSPECIFIED
Anvari, E.UNSPECIFIED
Nguewa, P.UNSPECIFIED
Rashidi, S.UNSPECIFIED
Keywords: Diagnostic marker malaria Plasmodium falciparum proteomics vaccine target DNA vaccine malaria proteins surface gametocytes antigens immunogenicity sequestration transmission organelles Parasitology
Divisions:
Page Range: pp. 1255-1262
Journal or Publication Title: Parasitology
Journal Index: ISI
Volume: 147
Number: 12
Identification Number: https://doi.org/10.1017/s003118202000102x
ISSN: 0031-1820
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3039

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