Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Evaluation of biofilm formation and anti-biofilm properties of Peganum harmala and Crocus sativus in shigella flexneri clinical isolates

Wed Feb 28 22:39:30 2024

(2019) Evaluation of biofilm formation and anti-biofilm properties of Peganum harmala and Crocus sativus in shigella flexneri clinical isolates. Open Microbiology Journal. pp. 297-300. ISSN 18742858 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Background: Biofilm formation causes many serious problems in the treatment of bacterial infections. In addition, chronic infections due to biofilm formation can pose a huge burden to the health care systems. Also, many bacteria are biofilm producers as an important strategy for pathogenicity. Furthermore, the traditional use of herbal medicines such as Peganum harmala and Crocus sativus in Iran is interesting. Objective: The purpose of the current study was to investigate the biofilm formation in Shigella flexneri clinical isolates and to evaluate the anti-biofilm properties of P. harmala and C. sativus on Shigella flexneri clinical isolates. Methods: For the study purpose, Thirty S.flexneri clinical isolates were collected from Ahvaz, Iran. Then, the collected bacteria were subjected to biofilm formation assay. Afterward, P. harmala and C. sativus were applied as an anti-biofilm formation in S. flexneri. Results & Conclusion: Our results demonstrated that a significant number of samples were identified as strong biofilm producers. Then, P. harmala and C. sativus in a concentration of 30μg/ml and 60μg/ml were able to eradicate a strong biofilm formation in S. flexneri, respectively. In addition, it seems that more extensive studies and in vivo research should be done to confirm their properties. © 2019 Jalili.

Item Type: Article
Creators:
CreatorsEmail
Jalili, M.UNSPECIFIED
Amraei, M.UNSPECIFIED
Sadeghifard, N.UNSPECIFIED
Ghafourian, S.UNSPECIFIED
Keywords: Biofilm formation Crocus sativus P. harmala Peganum harmala S. flexneri Shigella flexneri antibiofilm activity article herbal medicine in vivo study Iran nonhuman
Divisions:
Page Range: pp. 297-300
Journal or Publication Title: Open Microbiology Journal
Journal Index: Scopus
Volume: 13
Number: 1
Identification Number: https://doi.org/10.2174/1874285801913010297
ISSN: 18742858 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2893

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