Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Anti-diabetic effect of a novel nano polymer of thymol in streptozotocin-induced diabetic wistar rats

Fri Apr 12 18:21:24 2024

(2019) Anti-diabetic effect of a novel nano polymer of thymol in streptozotocin-induced diabetic wistar rats. International Journal of Applied Pharmaceutics. pp. 81-89. ISSN 09757058 (ISSN)

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Objective: The aim of this study was to evaluate the effect of thymol and thymol nano polymer on the blood biochemical parameters and antidiabetic activity in Streptozotocin (STZ)-induced diabetic rats. Methods: The synthesized nano polymer (NP) was characterized by using different spectroscopy methods, such as IR, HNMR and CNMR. Loading and releasing of thymol were investigated by HPLC. Eleven groups of the Streptozotocin-induced diabetic and normal rats (overall 110 males) were tested through various biochemical factors such as: serum glucose, insulin, liver function-related enzymes including ALT, AST, ALP and bilirubin by ELISA kit methods. Results: It has shown that thymol nano polymer is desirable for transferring drug. The amount of thymol loaded on NP estimated at 43±2.5 . Then, 65 of the loaded drug was released. LD50 for thymol and thymol nano polymer were 435 and 583 mg/kg, respectively. thymol nano polymer at doses of 30, 60 and 90 mg/kg, in a dose-dependent manner, reduced blood glucose, increased insulin levels, and controlled liver enzymes ALT, AST, ALP and bilirubin in the STZ-induced diabetic rats. Conclusion: The use of thymol nano polymer appears to be a new aspect concerning to protect diabetes-induced damage in the animal model. © 2019 The Authors.

Item Type: Article
Ghaneialvar, H.UNSPECIFIED
Mohammadpour, S.UNSPECIFIED
Keywords: Diabetes Drug delivery Nano polymer Streptozotocin Thymol alanine aminotransferase alkaline phosphatase aspartate aminotransferase bilirubin glibenclamide insulin oleic acid polymer animal experiment animal model antidiabetic activity Article biochemical analysis body weight loss carbon nuclear magnetic resonance controlled study drug release encapsulation enzyme linked immunosorbent assay glucose blood level hyperglycemia infrared spectroscopy insulin release LD50 liver function male nonhuman proton nuclear magnetic resonance rat reversed phase high performance liquid chromatography streptozotocin-induced diabetes mellitus toxicity testing
Page Range: pp. 81-89
Journal or Publication Title: International Journal of Applied Pharmaceutics
Journal Index: Scopus
Volume: 11
Number: 5
Identification Number:
ISSN: 09757058 (ISSN)
Depositing User: مهندس مهدی شریفی

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