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 مخزن اطلاعات پژوهشی و تحقیقاتی

مخزن اطلاعات پژوهشی و تحقیقاتی

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Increased Expression of Toll-Like Receptors 2 and 4 in Renal Transplant Recipients that Develop Allograft Dysfunction: A Cohort Study

(2017) Increased Expression of Toll-Like Receptors 2 and 4 in Renal Transplant Recipients that Develop Allograft Dysfunction: A Cohort Study. Iranian journal of immunology : IJI.

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آدرس رسمی: https://www.scopus.com/inward/record.uri?eid=2-s2....

چکیده انگلیسی

BACKGROUND: The incidence of ischemic reperfusion injury (IRI) in early phase post-transplantation and activation of toll-like receptor (TLR-2) and TLR-4 remarkably impact the outcome of a renal allograft. OBJECTIVE: To investigate whether the expression of TLRs in peripheral blood mononuclear cells (PBMCs) can predict the clinical outcome of kidney allografts. METHODS: We obtained blood samples from 52 renal transplant patients before transplant, and 2, 90, and 180 days post-transplantation in order to analyze the surface expressions of TLR-2 and TLR-4 on peripheral blood monocytes. The expression patterns of TLR-2 and TLR-4 were compared between patients with graft dysfunction (GD) and those with well-functioning graft (WFG). RESULTS: Significantly different mean dynamic changes in surface expression of TLR-2 according to percentage of TLR-2+ cells between (the GD and WFG) groups existed at most time-points before and after renal transplantation (p=0.007) with the exception of day 2 post-transplantation. We observed significantly higher mean fluorescence intensities of TLR-2 and TLR-4 on CD14+ cells in the GD group compared to the WFG group. This finding was particularly observed 180 days post-transplantation (p=0.001). Based on TLR-2 and TLR-4 protein expression for each step, multiple logistic regression and ROC curve analysis revealed that an increase in CD14+ TLR-2+ monocytes within the 90 days post-transplantaton was associated with increased risk of GD at 180 and 365 days post-transplantation odds ratio (OR)=1.27, p=0.005). CONCLUSION: Sequential monitoring of TLR-2 and TLR-4 expression patterns in peripheral blood monocytes appear to be prognostic and predictive biomarkers for early and late kidney allograft outcomes.

نوع سند : مقاله
Additional Information: cited By 0
زبان سند: انگلیسی
کلید وازه ها (انگلیسی): biological marker; CD14 antigen; TLR2 protein, human; TLR4 protein, human; toll like receptor 2; toll like receptor 4, adult; allograft; cohort analysis; female; follow up; graft recipient; human; immunology; kidney transplantation; male; metabolism; middle aged; mononuclear cell; primary graft dysfunction; prognosis; risk, Adult; Allografts; Antigens, CD14; Biomarkers; Cohort Studies; Female; Follow-Up Studies; Humans; Kidney Transplantation; Leukocytes, Mononuclear; Male; Middle Aged; Primary Graft Dysfunction; Prognosis; Risk; Toll-Like Receptor 2; Toll-Like Receptor 4; Transplant Recipients
کاربر ارسال کننده: mahdi sharifi
URI: http://eprints.medilam.ac.ir/id/eprint/2878

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Fri Dec 14 23:29:35 2018