(2020) Protective effect of Nectaroscordum tripedale extract and its bioactive component tetramethylpyrazine against acetaminophen-induced hepatotoxicity in rats. Advances in Traditional Medicine. ISSN 26624052 (ISSN)
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Abstract
Hepatoxicity is a common complication of acetaminophen. This study was to evaluate the effects of Nectaroscordum tripedale extract (NTE) and its bioactive component tetramethylpyrazine (TMP) on acetaminophen-induced liver failure. The presence of TMP in NTE was determined by HPLC. The hepatoprotective effect of NTE and TMP (50, 100 and 200 mg/kg, respectively) was evaluated by the assay of liver function parameters; total bilirubin, alanine aminotransaminase (ALT), aspartate aminotransaminase (AST), alkaline phosphatase activities (ALP) and superoxide dismutase (SOD). Results revealed that TMP was 1.24 mg/g in NTE. LD50 of the NTE and TMP was 3800 mg/kg and 2700 mg/kg, respectively. NTE and TMP (100 and 200 mg/kg) decreased the ALT, AST, ALP, and bilirubin but the SOD increased in a dose-dependent manner in acetaminophen-induced liver failure rats. In conclusion, NTE and its fraction TMP may be a protecting liver candidate against acetaminophen-induced hepatotoxicity. © 2020, Institute of Korean Medicine, Kyung Hee University.
| Item Type: | Article | ||||||||||||
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| Keywords: | Acetaminophen HPLC Liver failure Nectaroscordum tripedale Tetramethylpyrazine | ||||||||||||
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| Journal or Publication Title: | Advances in Traditional Medicine | ||||||||||||
| Journal Index: | Scopus | ||||||||||||
| Identification Number: | https://doi.org/10.1007/s13596-020-00431-z | ||||||||||||
| ISSN: | 26624052 (ISSN) | ||||||||||||
| Depositing User: | مهندس مهدی شریفی | ||||||||||||
| URI: | http://eprints.medilam.ac.ir/id/eprint/2861 |
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