Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The role of childhood maltreatment in cortisol in the hypothalamic–pituitary–adrenal (HPA) axis in methamphetamine-dependent individuals with and without depression comorbidity and suicide attempts

Wed Nov 30 07:58:15 2022

(2020) The role of childhood maltreatment in cortisol in the hypothalamic–pituitary–adrenal (HPA) axis in methamphetamine-dependent individuals with and without depression comorbidity and suicide attempts. Journal of Affective Disorders. pp. 274-281. ISSN 01650327 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Background: The hypothalamic–pituitary–adrenal (HPA) axis dysregulation which was found to have an important role in the pathophysiology of depression, suicide, and substance dependence, may be influenced by childhood maltreatment (CM). The present study aimed to investigate the relationship between CM and cortisol changes in methamphetamine-dependent individuals. Methods: In a cross-sectional study, methamphetamine-dependent individuals (n = =195) with or without both comorbid major depressive disorder (MDD) and a history of suicide attempts were selected and completed the Childhood Trauma Questionnaire-Short Form (CTQ-SF), the Beck Scale for Suicide Ideation (BSSI), and the Beck Depression Inventory-II (BDI-II). To assess cortisol levels, saliva samples were collected at six time intervals for two consecutive days. Results: A history of CM significantly predicted wake-up cortisol level, cortisol awakening response (CAR), and diurnal cortisol slope. Methamphetamine-dependent individuals with both MDD and lifetime suicide attempts had higher CM and higher cortisol levels with a blunted diurnal cortisol slope than individuals who were merely methamphetamine-dependent. Individuals with high CM showed higher cortisol levels with a blunted diurnal slope than those with low or without CM. Limitations: Cross-sectional data and use of self-report scales, especially retrospective measurements (e.g., the CTQ-SF), were important limitations of this study. Conclusion: Findings suggest that methamphetamine-dependent individuals with adverse psychological factors such as CM, MDD, and suicide attempts may show dysregulation in biological factors including cortisol level. In addition, CM and its effects on cortisol in the HPA axis may emerge as important factors regarding psychopathological use of methamphetamine. © 2019 Elsevier B.V.

Item Type: Article
Creators:
CreatorsEmail
Pirnia, B.UNSPECIFIED
Khosravani, V.UNSPECIFIED
Maleki, F.UNSPECIFIED
Kalbasi, R.UNSPECIFIED
Pirnia, K.UNSPECIFIED
Malekanmehr, P.UNSPECIFIED
Zahiroddin, A.UNSPECIFIED
Keywords: Childhood maltreatment Cortisol Depression Methamphetamine Suicide hydrocortisone adult Article Beck Depression Inventory Beck Scale for Suicide Ideation behavior disorder assessment child abuse Childhood Trauma Questionnaire controlled study cross-sectional study emotional abuse emotional neglect female human hypothalamus hypophysis adrenal system major clinical study major depression male medical history methamphetamine dependence neglect physical abuse priority journal retrospective study saliva level self report sexual abuse suicide attempt
Divisions:
Page Range: pp. 274-281
Journal or Publication Title: Journal of Affective Disorders
Journal Index: Scopus
Volume: 263
Identification Number: https://doi.org/10.1016/j.jad.2019.11.168
ISSN: 01650327 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2854

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