Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

High-throughput particle concentration using complex cross-section microchannels

Fri Jul 1 21:11:22 2022

(2020) High-throughput particle concentration using complex cross-section microchannels. Micromachines. ISSN 2072666X (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

High throughput particle/cell concentration is crucial for a wide variety of biomedical, clinical, and environmental applications. In this work, we have proposed a passive spiral microfluidic concentrator with a complex cross-sectional shape, i.e., a combination of rectangle and trapezoid, for high separation efficiency and a confinement ratio less than 0.07. Particle focusing in our microfluidic system was observed in a single, tight focusing line, in which higher particle concentration is possible, as compared with simple rectangular or trapezoidal cross-sections with similar flow area. The sharper focusing stems from the confinement of Dean vortices in the trapezoidal region of the complex cross-section. To quantify this effect, we introduce a new parameter, complex focusing number or CFN, which is indicative of the enhancement of inertial focusing of particles in these channels. Three spiral microchannels with various widths of 400 μ m, 500 μ m, and 600 μ m, with the corresponding CFNs of 4.3, 4.5, and 6, respectively, were used. The device with the total width of 600 μ m was shown to have a separation efficiency of ~98, and by recirculating, the output concentration of the sample was 500 times higher than the initial input. Finally, the investigation of results showed that the magnitude of CFN relies entirely on the microchannel geometry, and it is independent of the overall width of the channel cross-section. We envision that this concept of particle focusing through complex cross-sections will prove useful in paving the way towards more efficient inertial microfluidic devices. © 2020 by the authors.

Item Type: Article
Creators:
CreatorsEmail
Mihandoust, A.UNSPECIFIED
Bazaz, S. R.UNSPECIFIED
Maleki-Jirsaraei, N.UNSPECIFIED
Alizadeh, M.UNSPECIFIED
Taylor, R. A.UNSPECIFIED
Warkiani, M. E.UNSPECIFIED
Keywords: Complex cross-section Inertial microfluidics Particle/cell concentrator Efficiency Fluidic devices Focusing Microchannels Complex cross-sections Environmental applications High separation efficiency Microchannel geometries Output concentrations Particle concentrations Trapezoidal cross sections Microfluidics
Divisions:
Journal or Publication Title: Micromachines
Journal Index: Scopus
Volume: 11
Number: 4
Identification Number: https://doi.org/10.3390/MI11040440
ISSN: 2072666X (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2841

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