Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The effect of intrathecal meperidine on maternal and newborn outcomes after cesarean section: A systematic review and meta-analysis study

Mon Sep 26 22:58:43 2022

(2020) The effect of intrathecal meperidine on maternal and newborn outcomes after cesarean section: A systematic review and meta-analysis study. Anesthesiology and Pain Medicine. ISSN 22287523 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Context: Spinal anesthesia is the most preferred method for cesarean section. This meta-analysis was performed to determine the effect of minimum and maximum intrathecal doses of meperidine (pethidine) 5 to 40 mg on the maternal and newborn outcomes after cesarean section. Evidence Acquisition: The data were collected through the systematic search in the ISI, PubMed, Scopus, Google Scholar, Barakat, MagIran, SID, Irandoc, and EMBASE medical databases. Eighteen clinical trial studies with 1,494 patients were included. Results: Patients who had received intrathecal meperidine had experienced lower shivering, relative risk RR = 0.34 (95% CI = 0.23, 0.48) and longer analgesia, standard mean difference (SMD) = 7.67 (95% CI = 1.85, 13.49) after the surgery. Moreover, RR of nausea = 1.37 (95% CI = 1.13, 1.66), vomiting RR = 2.02 (95% CI = 1.28, 3.20), and pruritus RR = 9.26 (95% CI = 4.17, 20.58) was higher in the pethidine group than in the control group. There was no statistically significant difference in the Apgar score at one-minute RR = 0.99 (95% CI = 0.9, 1.09), at five-minute RR = 0.93 (95% CI = 0.87, 1.08), maternal hypotension RR = 1.00 (95% CI = 0.87, 1.15), and maternal sensory and motor blockade durations, SMD =-1.72 (95% CI =-3.78.0.34) and SMD =-4.38 (95% CI =-9.19, 0.44), respectively in the two pethidine and control groups. Conclusions: Intrathecal meperidine can reduce shivering and increase the duration of postoperative analgesia, though it increases the relative risk of nausea, vomiting, and pruritus. No significant difference was found both in the Apgar score, maternal hypotension, and duration of the motor and sensory block. © 2020, Anesthesiology and Pain Medicine.

Item Type: Article
Creators:
CreatorsEmail
Jaafarpour, M.UNSPECIFIED
Taghizadeh, Z.UNSPECIFIED
Shafiei, E.UNSPECIFIED
Vasigh, A.UNSPECIFIED
Sayehmiri, K.UNSPECIFIED
Keywords: Cesarean Section Injections Meperidine Mothers Spinal
Divisions:
Journal or Publication Title: Anesthesiology and Pain Medicine
Journal Index: Scopus
Volume: 10
Number: 2
Identification Number: https://doi.org/10.5812/aapm.100375
ISSN: 22287523 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2838

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