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Ilam University of Medical Sciences

L and S alleles of 5HTTLPR polymorphism of SLC6A4 gene in healthy people and patients with severe depression in Ilam province, Iran

Mon Nov 28 12:09:28 2022

(2020) L and S alleles of 5HTTLPR polymorphism of SLC6A4 gene in healthy people and patients with severe depression in Ilam province, Iran. Meta Gene. ISSN 22145400 (ISSN)

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Abstract

Background: The serotonin transporter (5HTT) is a protein locating on the presynaptic neuron membrane. The genes coding for 5HTT has 6 separate families, of which, SLC6A4. Polymorphism in the promoter region of SLC6A4 (5HTTLPR) has been shown to correlate with personality traits. This study aimed to compare the L and S alleles of 5HTTLPR in healthy people and patients with severe depression in the Ilam province, Iran. Methods: In this study, 198 patients with depression and 100 volunteers enrolled. The DNA of samples was extracted and PCR was performed. After electrophoresis, PCR product was identified on 2 gel electrophoresis to distinguish SS, LS and LL bands. Finally, data were analyzed using chi-square and logistic regression. Results: The frequency of analysis of 5HTTLPR alleles in healthy subjects and patients was as follows: In healthy group genotypes were LS 44, LL 49, SS 7 and in the patient group were LS 39.9, LL 23.7, and SS 36.4. Further analysis showed that the frequency of genotypes in patients was significantly associated with psychological trauma (P = 0 .001). Our results also showed that S/S genotype was associated with a 6.2 fold onset of depression. Conclusion: The results of this study showed that the health status of individuals was significantly correlated with the frequency of SS genotype that was higher in the patient group. © 2020 Elsevier B.V.

Item Type: Article
Creators:
CreatorsEmail
Pooyan, F.UNSPECIFIED
Gheysarzdeh, A.UNSPECIFIED
Sadeghifard, N.UNSPECIFIED
Kikhavani, S.UNSPECIFIED
Keywords: 5HTTLPR polymorphism Depression Serotonin SLC6A4 gene The serotonin transporter protein adult allele Article controlled study DNA extraction DNA polymorphism female gene gene expression gene frequency General Health Questionnaire genotype human Iran major clinical study male mental health polymerase chain reaction priority journal
Divisions:
Journal or Publication Title: Meta Gene
Journal Index: Scopus
Volume: 25
Identification Number: https://doi.org/10.1016/j.mgene.2020.100716
ISSN: 22145400 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2827

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