Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Fabrication of Pd NPs on pectin-modified Fe3O4 NPs: A magnetically retrievable nanocatalyst for efficient C–C and C–N cross coupling reactions and an investigation of its cardiovascular protective effects

Tue Jun 25 06:19:54 2024

(2020) Fabrication of Pd NPs on pectin-modified Fe3O4 NPs: A magnetically retrievable nanocatalyst for efficient C–C and C–N cross coupling reactions and an investigation of its cardiovascular protective effects. International Journal of Biological Macromolecules. pp. 1252-1262. ISSN 01418130 (ISSN)

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The present report represents the synthesis of a novel Pd NPs immobilized over a natural polysaccharide (pectin) coated Fe3O4 magnetic nanocomposite material (Fe3O4@pectin/Pd) for investigating the cardiovascular protective effects. The biomolecular functionalization not only stabilizes the ferrite nanoparticles from agglomeration but also provides an environment for the biogenic reduction of Pd2+ ions. This protocol is a promising breakthrough for the synthesis of a quasi-heterogeneous catalyst, a bridge between heterogeneous and homogeneous medium. The structure, morphology and physicochemical properties of the material were characterized utilizing various analytical techniques like FT-IR, FE-SEM, TEM, VSM, EDX-elemental mapping, ICP, EDX and XPS. The catalyst showed excellent reactivity in C-C and C-N cross coupling reactions via Suzuki and Buchwald-Hartwig reactions respectively. An array of different biphenyls and aryl amines were then procured by reactions of various aryl halides with phenylboronic acid or secondary amines over the catalyst affording good to excellent yields. The catalyst was easily recoverable using an external magnet and thereafter recycled for several trials with insignificant palladium leaching or loss in catalytic performance. To investigate the cardiovascular protective activities of catalyst, the MTT assay was done on Human Aortic Endothelial Cells (HAEC), Human Coronary Artery Endothelial Cells (HCAEC), and Human Pulmonary Artery Endothelial Cells (HPAEC) cell lines. Nanocatalyst-treated cell cutlers significantly (p ≤ 0.01) decreased the caspase-3 activity, and DNA fragmentation. It raised the cell viability and mitochondrial membrane potential in the high concentration of Mitoxantrone-treated HAEC, HCAEC, and HPAEC cells. According to the above findings, nanocatalyst can be administrated as a cardiovascular protective drug for the treatment of cardiovascular diseases after approving in the clinical trial studies in humans. © 2018 Elsevier B.V.

Item Type: Article
Keywords: Cardiovascular protective drug Cell death Mitoxantrone Nanocatalyst Pd NPs Pectin-modified Fe3O4 NPs aromatic amine benzeneboronic acid biphenyl derivative carbon caspase 3 nitrogen palladium nanoparticle pectin ultrasmall superparamagnetic iron oxide aortic endothelial cell apoptosis index Article CAEC cell line cardiovascular disease cell culture cell viability concentration (parameter) controlled study cross coupling reaction DNA fragmentation drug delivery system drug stability drug structure drug synthesis energy dispersive X ray spectroscopy enzyme activity Fourier transform infrared spectroscopy heart protection human human cell inductively coupled plasma mass spectrometry mitochondrial membrane potential MTT assay nanofabrication physical chemistry pulmonary artery scanning electron microscopy Suzuki reaction transmission electron microscopy vibrating sample magnetometry X ray photoemission spectroscopy
Page Range: pp. 1252-1262
Journal or Publication Title: International Journal of Biological Macromolecules
Journal Index: Scopus
Volume: 160
Identification Number:
ISSN: 01418130 (ISSN)
Depositing User: مهندس مهدی شریفی

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