Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Evaluation of putative toxin-antitoxins systems in clinical Brucella melitensis in Iran

Wed Nov 30 07:44:53 2022

(2020) Evaluation of putative toxin-antitoxins systems in clinical Brucella melitensis in Iran. Infectious disorders drug targets. ISSN 2212-3989 (Electronic) 1871-5265 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/31957618

Abstract

BACKGROUND: Toxin-antitoxin systems (TAs) are two-component elements, which are extensive in the bacterial genome and have a regulatory role in many cellular activities including, growth arrest, survival, biofilm formation, and bacterial persistence. OBJECTIVE: TAs have not well studied in Brucella spp. METHODS: We evaluated the presence of different toxin-antitoxin systems, including relE- rhh-like, Fic- Phd, Cog- Rhh, and cogT- cogAT in 40 clinical Brucella melitensis isolates using PCR-based sequencing assay. RESULTS: Our results showed the high presence of relE-rhh-like, Fic-Phd, Cog-rhh, and cogT-cogAT s TAs genes in B. melitensis isolates that were 96.25, 92.5, 96.25, and 95, respectively. CONCLUSION: A high presence of TAs genes in clinical B. melitensis isolates revealed that the TA system could be an antibacterial target in B. melitensis but more investigation is necessitated to elucidate the exact roles of these genes.

Item Type: Article
Creators:
CreatorsEmail
Moradkasani, S.UNSPECIFIED
Kouhsari, E.UNSPECIFIED
Jazi, F. M.UNSPECIFIED
Kalani, B. S.UNSPECIFIED
Pakzad, I.UNSPECIFIED
Keywords: Brucella melitensis Cog- Rhh Fic- Phd Toxin-antitoxin systems cogT- cogAT relE- rhh-like
Divisions:
Journal or Publication Title: Infectious disorders drug targets
Journal Index: Pubmed
Identification Number: https://doi.org/10.2174/1871526520666200117113420
ISSN: 2212-3989 (Electronic) 1871-5265 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2823

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