Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Minocycline, focus on mechanisms of resistance, antibacterial activity, and clinical effectiveness: Back to the future

(2020) Minocycline, focus on mechanisms of resistance, antibacterial activity, and clinical effectiveness: Back to the future. Journal of global antimicrobial resistance. pp. 161-174. ISSN 2213-7173 (Electronic) 2213-7165 (Linking)

Full text not available from this repository.

Official URL: https://www.ncbi.nlm.nih.gov/pubmed/32061815

Abstract

OBJECTIVES: The increasing crisis regarding multidrug-resistant (MDR) and extensively drug-resistant microorganisms leads to appealing therapeutic options. METHODS: During the last 30 years, minocycline, a wide-spectrum antimicrobial agent, has been effective against MDR Gram-positive and Gram-negative bacterial infections. As with other tetracyclines, the mechanism of action of minocycline involves attaching to the bacterial 30S ribosomal subunit and preventing protein synthesis. RESULTS: This antimicrobial agent has been approved for the treatment of acne vulgaris, some sexually transmitted diseases and rheumatoid arthritis. Although many reports have been published, there remains limited information regarding the prevalence, mechanism of resistance and clinical effectiveness of minocycline. CONCLUSION: Thus, we summarize here the currently available data concerning pharmacokinetics and pharmacodynamics, mechanism of action and resistance, antibacterial activity and clinical effectiveness of minocycline.

Item Type: Article
Keywords: Mechanisms of minocycline resistance Minocycline antibacterial activity Minocycline clinical effectiveness Minocycline resistance
Divisions:
Page Range: pp. 161-174
Journal or Publication Title: Journal of global antimicrobial resistance
Journal Index: Pubmed
Volume: 22
Identification Number: https://doi.org/10.1016/j.jgar.2020.01.022
ISSN: 2213-7173 (Electronic) 2213-7165 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2818

Actions (login required)

View Item View Item