Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Incidence, Clinical Manifestation, Treatment Outcome, and Drug Susceptibility Pattern of Nontuberculous Mycobacteria in HIV Patients in Tehran, Iran

Sat Dec 10 02:32:41 2022

(2020) Incidence, Clinical Manifestation, Treatment Outcome, and Drug Susceptibility Pattern of Nontuberculous Mycobacteria in HIV Patients in Tehran, Iran. Ethiopian Journal of Health Sciences. pp. 75-84. ISSN 2413-7170 (Electronic) 1029-1857 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/32116435

Abstract

Background: Nontuberculous mycobacterial (NTM) infections have radically increased worldwide due to the increase in HIV infections. The disease activity increases with progressive immunodeficiency. Methods: A total of 216 HIV seropositive patients suspected of having mycobacterial infection were recruited for this study. Clinical samples were collected from each patient and cultured on Lowenstein-Jensen media. Detection and species identification were simultaneously done using Reverse Blot Hybridization Assay System. Also, the minimum inhibitory concentrations (MIC) for each isolate were determined in 7H9 broth media for 10 antibiotics. Results: In this study, 4 rapid and 4 slow-growing NTM species were isolated and identified. Mycobacterium fortuitum was the most common NTM species, 3/8 (37.5), followed by Mycobacterium kansasii, 2/8 (25). The cases were identified as pulmonary disease, 5/8 (62.5 ), disseminated infection, 2/8 (25), and skin abscess, 1/8 (12.5). M. chelonae and Mycobacterium avium were isolated from patients diagnosed with disseminated infection with treatment failure. The skin abscess was caused by infection with M. simiae. The results of the MIC testing were as follows: M. kansasii and M. fortuitum were susceptible to amikacin (AMK); M. avium to clarithromycin (CLA); M. fortuitum 2/3 (67) to ciprofloxacin (CIP); 1/2 (50) of M. kansasii isolates to CLA, and M. chelonae to rifampin (RIF), linezolid (LIN), AMK, and CIP at medium and high concentrations. Conclusion: AMK showed incredible in vitro activity against M. kansasii and M. fortuitum. Also, M. avium was susceptible to CLA, whereas M. simiae and M. chelonae were resistant to the tested drugs in this study.

Item Type: Article
Creators:
CreatorsEmail
Feysia, S. G.UNSPECIFIED
Hasan-Nejad, M.UNSPECIFIED
Amini, S.UNSPECIFIED
Hamzelou, G.UNSPECIFIED
Kazemian, H.UNSPECIFIED
Kardan-Yamchi, J.UNSPECIFIED
Karami-Zarandi, M.UNSPECIFIED
Feizabadi, M. M.UNSPECIFIED
Keywords: Abscess Microdilution Minimum inhibitory concentrations Nontuberculous mycobacteria
Divisions:
Page Range: pp. 75-84
Journal or Publication Title: Ethiopian Journal of Health Sciences
Journal Index: Pubmed
Volume: 30
Number: 1
Identification Number: https://doi.org/10.4314/ejhs.v30i1.10
ISSN: 2413-7170 (Electronic) 1029-1857 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2816

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