Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Role of autophagy in the pathogenesis of rheumatoid arthritis: Latest evidence and therapeutic approaches

Sat Dec 10 02:34:04 2022

(2020) Role of autophagy in the pathogenesis of rheumatoid arthritis: Latest evidence and therapeutic approaches. Life sciences. p. 117734. ISSN 1879-0631 (Electronic) 0024-3205 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/32380080

Abstract

Autophagy is considered as an important intracellular mechanism that degrades cytoplasmic components to furnish additional energy. It has cytoprotective effects through the degradation of intracellular pathogens, damaged organelles, and protein aggregates. On the other hand, there are reports of an association between autophagy and autoimmune diseases. Indeed, it has been evident that autophagy is dysregulated in various autoimmune diseases including rheumatoid arthritis (RA). Autophagy is implicated in the maturation survival and proliferation of various immune and non-immune cells, which play pivotal roles in RA pathogenesis. Additionally, autophagy seems to be involved in citrullination and presentation of citrullinated peptides to T lymphocyte cells. Presentation of citrullinated peptides through MHC compartments to the T cells leads to immune response and chronic inflammation. Evidence suggests that autophagy could be implicated in apoptosis resistance of RA fibroblast-like synoviocyte (RA FLS), osteoclastogenesis, and finally severe bone and cartilage destruction. Since autophagy could be an important phenomenon in RA pathogenesis, we summarized the roles of autophagy in citrullination, osteoclastogenesis, RA FLS cells survival, apoptosis resistance of cells, lymphocyte homeostasis and its clinical outcomes in RA disease.

Item Type: Article
Creators:
CreatorsEmail
Karami, J.UNSPECIFIED
Masoumi, M.UNSPECIFIED
Khorramdelazad, H.UNSPECIFIED
Bashiri, H.UNSPECIFIED
Darvishi, P.UNSPECIFIED
Sereshki, H. A.UNSPECIFIED
Shekarabi, M.UNSPECIFIED
Sahebkar, A.UNSPECIFIED
Keywords: Apoptosis resistance Autophagy Homeostasis Lymphocytes Osteoclasts Rheumatoid arthritis Rheumatoid arthritis fibroblast-like synoviocyte interest.
Divisions:
Page Range: p. 117734
Journal or Publication Title: Life sciences
Journal Index: Pubmed
Volume: 254
Identification Number: https://doi.org/10.1016/j.lfs.2020.117734
ISSN: 1879-0631 (Electronic) 0024-3205 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2801

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