Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

First Report on the Characteristics of Methicillin Resistant Staphylococcus Capitis Isolates and a NRCS-A-clone Related Isolate Obtained from Iranian Children

Thu Aug 11 15:19:03 2022

(2020) First Report on the Characteristics of Methicillin Resistant Staphylococcus Capitis Isolates and a NRCS-A-clone Related Isolate Obtained from Iranian Children. Infectious disorders drug targets. ISSN 2212-3989 (Electronic) 1871-5265 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/32389116

Abstract

BACKGROUND: Methicillin-resistant Staphylococcus capitis (MRSC) NRCS-A clone (Multi-resistant and vancomycin-non susceptible) has been recently described as an emerging cause of nosocomial bacteremia especially in neonatal intensive-care units (NICUs). OBJECTIVE: The objective of this study was to evaluate the antibiotic and antiseptic resistance patterns, biofilm producing ability and the prevalence of SCCmec and ACME types among MRSC isolates as well as to check the possible presence of NRCS-A clone at Tehran's Children's Medical Center, Iran. METHODS: A total of 256 coagulase negative Staphylococcal isolates were collected, of which 10 S. capitis isolates were obtained and tested for susceptibility against 13 antimicrobial and 3 antiseptic agents, as well as biofilm production. The presence of 15 distinct resistance genes, staphylococcal cassette chromosome mec (SCCmec), and arginine catabolic mobile elements (ACMEs) were tracked. RESULTS: Seven out of 10 S. capitis isolates were MRSC (MIC90 van=8mug/mL) and resistant to trimethoprim/sulfamethoxazole, produced biofilm, (3 as strong biofilm producers) and carried ACME types I and II. Despite the identification of mec and ccr complexes in some isolates, all the SCCmec cassettes were untypeable (UT). CONCLUSION: According to the studied features, only one isolate belonged to the NRSC-A clone. The results indicate that MRSC with high antibiotic resistance and unknown SCCmec might become a serious problem in the future for the treatment of patients particularly children.

Item Type: Article
Creators:
CreatorsEmail
Asadolahi, P.UNSPECIFIED
Farzan, B.UNSPECIFIED
Rezaei, F.UNSPECIFIED
Delfani, S.UNSPECIFIED
Ashrafi, B.UNSPECIFIED
Soroush, S.UNSPECIFIED
Keywords: Acme Biofilm NRCS-A clone SCCmec Staphylococcus capitis
Divisions:
Journal or Publication Title: Infectious disorders drug targets
Journal Index: Pubmed
Identification Number: https://doi.org/10.2174/1871526520666200511011309
ISSN: 2212-3989 (Electronic) 1871-5265 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2800

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