Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Fructose Feeding and Hyperuricemia: a Systematic Review and Meta-Analysis

Sun May 19 23:19:24 2024

(2020) Fructose Feeding and Hyperuricemia: a Systematic Review and Meta-Analysis. Clinical nutrition research. pp. 122-133. ISSN 2287-3732 (Print) 2287-3732 (Linking)

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High fructose feeding has been suggested to involve in several features of metabolic syndrome including hyperuricemia (HP). We designed and implemented a study to determine the effect size of fructose intake and the relative risk of HP based on the type of fructose feeding (diet or solution), duration of treatment (2-6, 7-10, and > 10 weeks), and animal race. The required information was accepted from international databases, including PubMed/MEDLINE, Science Direct, Scopus, and etc., from 2009 until 2019 on the basis of predetermined eligibility criteria. The data selection and extraction and quality assessment were performed independently by two researchers. Results were pooled as random effects weighting and reported as standardized mean differences with 95 confidence intervals. Thirty-five studies including 244 rats with fructose consumption were included in the final analysis. The heterogeneity rate of parameters was high (I2 = 81.3, p < 0.001) and estimated based on; 1) type of fructose feeding (diet; I2 = 79.3, solution 10; I2 = 83.4, solution 20; I2 = 81.3), 2) duration of treatment (2-6 weeks; I2 = 86.8, 7-10 weeks; I2 = 76.3, and > 10 weeks; I2 = 82.8), 3) the animal race (Wistar; I2 = 78.6, Sprague-Dawley; I2 = 83.9). Overall, the pooled estimate for the all parameters was significant (p < 0.001). The results of this study indicated that a significant relationship between HP and fructose intake regardless of the treatment duration, animal race, fructose concentration and route of consumption.

Item Type: Article
Keywords: Fructose Hyperuricemia Meta-analysis Rats Systematic review Uric acid
Page Range: pp. 122-133
Journal or Publication Title: Clinical nutrition research
Journal Index: Pubmed
Volume: 9
Number: 2
Identification Number:
ISSN: 2287-3732 (Print) 2287-3732 (Linking)
Depositing User: مهندس مهدی شریفی

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