Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Evaluation of type II toxin-antitoxin systems, antibiotic resistance profiles, and biofilm quorum sensing genes in Acinetobacter baumannii isolates in Iraq

Wed Nov 30 06:53:50 2022

(2020) Evaluation of type II toxin-antitoxin systems, antibiotic resistance profiles, and biofilm quorum sensing genes in Acinetobacter baumannii isolates in Iraq. Infectious disorders drug targets. ISSN 2212-3989 (Electronic) 1871-5265 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/32484105

Abstract

BACKGROUND: Bacterial Toxin-Antitoxin (TAs) systems are extensive two-component elements in the bacterial genome, which involved in many key biological functions including growth arrest, survival, biofilm formation, plasmid maintenance, defense against phages, persistence and virulence. AIM: This study aimed to assess the molecular determinants involved in TAs, biofilm quorum sensing, and antibiotic resistance profiles in Acinetobacter baumannii isolated from Baghdad`s hospitals in Iraq. METHODS: A total of 127 A. baumannii isolates were collected from 2160 different clinical samples. The antimicrobial susceptibility test was performed using disk diffusion test. All isolates were characterized for molecular determinants involved in TAs and biofilm formation using the well-known PCR-based sequencing assay. RESULTS: A high multi-drug resistant (MDR) (96.06; 122/127 ) and imipenem resistance (84.25; 107/127 ) rates were observed from A.baumannii isolates. Results showed the presence of rhlIR gene in three isolates (2.36), and lasIR gene appeared in two isolates (1.57) isolates, whilst, mazEF, ccdAB, and relBE genes have not detected among isolates. CONCLUSION: A high MDR and imipenem resistance rates within a low prevalence of rhlIR, and lasIR genes could be found in clinical A. baumannii isolates from some of Iraqi hospitals.

Item Type: Article
Creators:
CreatorsEmail
Al Marjania, M. F.UNSPECIFIED
Kouhsari, E.UNSPECIFIED
Ali, F. S.UNSPECIFIED
Authman, S. H.UNSPECIFIED
Keywords: Acinetobacter baumannii antibiotics resistance quorum sensing systems. toxin-antitoxin systems
Divisions:
Journal or Publication Title: Infectious disorders drug targets
Journal Index: Pubmed
Identification Number: https://doi.org/10.2174/1871526520666200525170318
ISSN: 2212-3989 (Electronic) 1871-5265 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2791

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