Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The Role of Peganum harmala Ethanolic Extract and Type II Toxin Antitoxin System in Biofilm Formation

Wed Nov 30 08:15:49 2022

(2017) The Role of Peganum harmala Ethanolic Extract and Type II Toxin Antitoxin System in Biofilm Formation. Drug Research. pp. 385-387. ISSN 2194-9379

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Abstract

Toxin antitoxin system is a regulatory system that antitoxin inhibits the toxin. We aimed to determine the role of TA loci in biofilm formation in K. pneumoniae clinical and environmental isolates; also inhibition of biofilm formation by Peganum harmala. So, 40 K. pneumoniae clinical and environmental isolates were subjected for PCR to determine the frequency of mazEF, relEB, and mqsRA TA loci. Biofilm formation assay subjected for all isolates. Then, P. harmala was tested against positive biofilm formation strains. Our results demonstrated that relBE TA loci were dominant TA loci; whereas mqsRA TA loci were negative in all isolates. The most environmental isolates showed weak and no biofilm formation while strong and moderate biofilm formation observed in clinical isolates. Biofilm formations by K. pneumoniae in 9 ug/ml concentration were inhibited by P. harmala. In vivo study suggested to be performed to introduce Peganum harmala as anti- biofilm formation in K. pneumoniae.

Item Type: Article
Creators:
CreatorsEmail
Valizadeh, N.UNSPECIFIED
Valian, F.UNSPECIFIED
Sadeghifard, N.UNSPECIFIED
Karami, S.UNSPECIFIED
Pakzad, I.UNSPECIFIED
Kazemian, H.UNSPECIFIED
Ghafourian, S.UNSPECIFIED
Keywords: Klebsiella pneumoniae biofilm formation Peganum harmala bacteria Pharmacology & Pharmacy Chemistry
Divisions:
Page Range: pp. 385-387
Journal or Publication Title: Drug Research
Journal Index: ISI
Volume: 67
Number: 7
Identification Number: https://doi.org/10.1055/s-0043-102060
ISSN: 2194-9379
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/277

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