Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Wound healing activity of Pimpinella anisum methanolic extract in streptozotocin-induced diabetic rats

Sun Sep 25 18:07:10 2022

(2019) Wound healing activity of Pimpinella anisum methanolic extract in streptozotocin-induced diabetic rats. Journal of Wound Care. S26-S36. ISSN 0969-0700

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Abstract

Objective: To assess the wound healing potential of Pimpinella anisum on cutaneous wounds in diabetic rats. Method: Full-thickness excisional wounds were made on the back of male, Sprague-Dawley rats with diabetes. The rats were randomly allocated into four treatment groups: 1 ml basal cream; tetracycline (3); Pimpinella anisum 10 for 14 days; and a control group. At days seven, 14 and 21 post-injury, five animals of each group were euthanised, and wounds were assessed through gross, histopathological and oxidant/antioxidant evaluations. Additionally, the dry matter and hydroxyproline contents of the skin samples were measured. Results: A total of 60 rats were used in the study. A significant decrease in the wound size was observed in treated animals with Pimpinella anisum compared with other groups during the experiment. Additionally, treatment with Pimpinella anisum decreased the number of lymphocytes and improved the number of fibroblasts at the earlier stages and increased a number of fibrocytes at the later stages of wound healing. Other parameters such as re-epithelialisation, tissue alignment, greater maturity of collagen fibres and large capillary-sized blood vessels revealed significant changes when compared with the control. Pimpinella anisum significantly reverted oxidative changes of total antioxidant capacity, malondialdehyde and glutathione peroxidase induced by diabetic wounds (p<0.05). Furthermore, it significantly increased the dry matter and hydroxyproline contents at various stages of wound healing (p<0.05). Conclusion: The present study showed that application of Pimpinella anisum extract promotes wound healing activity in diabetic rats. The wound-healing property of Pimpinella anisum can be attributed to the phytoconstituents present in the plant.

Item Type: Article
Creators:
CreatorsEmail
Hashemnia, M.UNSPECIFIED
Nikousefat, Z.UNSPECIFIED
Mohammadalipour, A.UNSPECIFIED
Zangeneh, M. M.UNSPECIFIED
Zangeneh, A.UNSPECIFIED
Keywords: diabetic rat methanolic extract Pimpinella anisum streptozotocin wound healing essential oil l. antioxidant model skin Dermatology
Divisions:
Page Range: S26-S36
Journal or Publication Title: Journal of Wound Care
Journal Index: ISI
Volume: 28
Number: 10
Identification Number: https://doi.org/10.12968/jowc.2019.28.Sup10.S26
ISSN: 0969-0700
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2725

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