Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Apelin-13 serum levels in type 2 diabetic obese women: possible relations with microRNAs-107 and 375

Mon Aug 15 11:34:43 2022

(2019) Apelin-13 serum levels in type 2 diabetic obese women: possible relations with microRNAs-107 and 375. Turkish Journal of Biochemistry-Turk Biyokimya Dergisi. pp. 667-675. ISSN 0250-4685

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Abstract

Objective: Apelin, an adipocytokine, is up-regulated by insulin and suppresses pancreatic insulin secretion. One of the key microRNAs in insulin resistance caused by obesity, is microRNA-107. MicroRNA-375 is expressed in the pancreatic islet cells. We aimed to explore apelin-13 and microRNA-107 and 375 in obese women with type 2 diabetes (T2D). Materials and Methods: Fifty obese women with newly diagnosed T2D and 50 non-diabetic obese women, as controls, were selected. Quantitative PCR and ELISA were used to measure the expression of microRNA-107 and 375 and Apelin-13 concentration, respectively. The role of apelin-13 was investigated in an in vitro model. Apoptosis was evaluated by flow cytometry. Results: Apelin-13 levels in diabetics were significantly more than controls (p = 0.012). The expressions of microRNA-107 and 375 of diabetic group were increased, in comparison to the control group. There was no correlation between apelin-13 and microRNA-107 and 375 in diabetic and control groups. Significant correlations between apelin-13 and serotonin (p <0.001) and estimated average glucose (p <0.02) and insulin (p <0.03) were only observed in the diabetic group. Conclusion: Serum levels of apelin-13 and circulating microRNA-107 and 375 could be used as biomarkers for diabetes, particularly in obese subjects. However, more study is needed in this field.

Item Type: Article
Creators:
CreatorsEmail
Ashoori, M. R.UNSPECIFIED
Rahmati-Yamchi, M.UNSPECIFIED
Ostadrahimi, A.UNSPECIFIED
Pahlavan-Gharebaba, R.UNSPECIFIED
Mobasseri, M.UNSPECIFIED
Bakhtiyari, S.UNSPECIFIED
Zarghami, N.UNSPECIFIED
Keywords: Apelin-13 MicroRNA-107 MicroRNA-375 Obesity Type 2 diabetes mellitus inhibits insulin-secretion adipose-tissue biomarkers adiponectin mellitus apj adipokines leptin ligand gene Biochemistry & Molecular Biology
Divisions:
Page Range: pp. 667-675
Journal or Publication Title: Turkish Journal of Biochemistry-Turk Biyokimya Dergisi
Journal Index: ISI
Volume: 44
Number: 5
Identification Number: https://doi.org/10.1515/tjb-2018-0157
ISSN: 0250-4685
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2723

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