Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Electrochemical determination of the antipsychotic medication clozapine by a carbon paste electrode modified with a nanostructure prepared from titania nanoparticles and copper oxide

Mon Sep 26 21:37:53 2022

(2019) Electrochemical determination of the antipsychotic medication clozapine by a carbon paste electrode modified with a nanostructure prepared from titania nanoparticles and copper oxide. Microchimica Acta. p. 10. ISSN 0026-3672

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Abstract

A nanostructure was prepared from titania nanoparticles and copper oxide (TiO2NP@CuO) and used to modify a carbon paste electrode (CPE). The modified CPE is shown to enable sensitive voltammetric determination of the drug clozapine (CLZ). The sensor was characterized by various techniques and some key parameters were optimized. Under the optimum conditions and at a working potential of 0.6 V (vs. Ag/AgCl), the modified CPE has two linear response ranges, one from 30 pmol L-1 to 4 nmol L-1 of CLZ, the other from 4 nmol L-1 to 10 mu mol L-1. The detection limit is as low as 9 pM. The transfer coefficient (alpha) and catalytic rate constant (k(cat)) were calculated and the reliability of the sensor was estimated for CLZ sensing in real samples where it gave satisfactory results.

Item Type: Article
Creators:
CreatorsEmail
Ghanbari, M. H.UNSPECIFIED
Shandost-Fard, F.UNSPECIFIED
Rostami, M.UNSPECIFIED
Khoshroo, A.UNSPECIFIED
Sobhani-Nasab, A.UNSPECIFIED
Gholipour, N.UNSPECIFIED
Salehzadeh, H.UNSPECIFIED
Ganjali, M. R.UNSPECIFIED
Rahimi-Nasrabadi, M.UNSPECIFIED
Ahmadi, F.UNSPECIFIED
Keywords: Titania nanoparticles Copper oxide Electrode modification Electrochemical sensor Nanomaterial voltammetric determination tungstate nanoparticles atypical antipsychotics chemical-synthesis sensor fabrication behavior Chemistry
Divisions:
Page Range: p. 10
Journal or Publication Title: Microchimica Acta
Journal Index: ISI
Volume: 186
Number: 11
Identification Number: https://doi.org/10.1007/s00604-019-3760-7
ISSN: 0026-3672
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2711

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