Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Surveying the relationship between Gly1057Asp polymorphism of IRS-2 gene and susceptibility to type 2 diabetes; a systematic review and meta-analysis study

Mon Nov 28 11:13:30 2022

(2019) Surveying the relationship between Gly1057Asp polymorphism of IRS-2 gene and susceptibility to type 2 diabetes; a systematic review and meta-analysis study. Journal of Renal Injury Prevention. pp. 263-270. ISSN 2345-2781

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Abstract

Type 2 diabetes mellitus (T2DM) is a multi-factorial disease in which influenced by several genetic and environmental factors. Insulin receptor substrate 2 (IRS 2) is the main mediator of insulin in the liver which controls insulin sensitivity. Gly1057Asp polymorphism is one of the candidates to increase risk of T2DM. The present study is an attempt to study the relationship of Gly1057Asp polymorphism of IRS-2 and T2DM by a meta-analysis. A systemic search was conducted in English and Persian databases such as Scopus, PubMed, Google Scholar, SID, and other academic databases for studies that have investigated the relationship of Gly1057Asp polymorphism of IRS-2 and T2DM. This association was determined using odds ratios (ORs) with a confidence interval of 95 (CIs). Heterogeneity of the studies was examined by I' index. Funnel plots and Egger tests were used to determine bias or publication bias. The collected data was analyzed in STATA through meta-analysis. Nine articles were selected as eligible for further analysis, which represented 3,196 patients with T2DM and 3409 controls subjects without T2DM. The present meta-analysis showed a significant relationship between GA genotype of Gly1057Asp polymorphism and T2DM (OR=0.88; 95 confidence interval, 0.79-0.98), whereas no significant relationship between GG and AA genotype with T2DM was seen; OR for GG and AA genotypes were 1.10 (95 CI, 0.99 -1.22) and 1.13 (95 CI, 0.95- 1.33), respectively. The results of our study show that genotype GA of Gly1057Asp polymorphism of IRS-2 gene plays a protective role and may decrease the risk of T2DM, whereas GG and AA genotypes are considered as a risk factor and related to development of T2DM to some extents.

Item Type: Article
Creators:
CreatorsEmail
Kiani, F.UNSPECIFIED
Sayehmiri, F.UNSPECIFIED
Dehkordi, A. H.UNSPECIFIED
Motedayen, M.UNSPECIFIED
Keywords: Type 2 diabetes mellitus Gly1057Asp polymorphism Meta-analysis receptor substrate-2 gene insulin-receptor g1057d polymorphism variant resistance gly972arg phosphorylation association sensitivity mechanisms Urology & Nephrology
Divisions:
Page Range: pp. 263-270
Journal or Publication Title: Journal of Renal Injury Prevention
Journal Index: ISI
Volume: 8
Number: 4
Identification Number: https://doi.org/10.15171/jrip.2019.50
ISSN: 2345-2781
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2693

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