Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Tear and serum MMP-9 and serum TIMPs levels in the severe sulfur mustard eye injured exposed patients

Tue Jul 5 17:26:55 2022

(2019) Tear and serum MMP-9 and serum TIMPs levels in the severe sulfur mustard eye injured exposed patients. International Immunopharmacology. p. 10. ISSN 1567-5769

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Abstract

Introduction: Sulfur mustard (SM) intoxication produces local and systemic changes in the human body. In this study, the relationship between tear and serum matrix metalloproteinase (MMP)-9 and serum tissue inhibitors of metalloproteinases (TIMPs) are assessed in serious eye-injured SM-exposed casualties. Methods: A group of 128 SM-exposed patients with serious ocular injuries in three subgroups (19 mild, 31 moderate, and 78 severe cases) is compared with 31 healthy controls. Tear and ocular status and serum MMPs and MMP-9/TIMPs complex levels were evaluated using enzyme-linked immunosorbent assay (ELISA). Results: Serum level of MMP-9 was significantly higher in the SM-exposed group compared to the control group (P = 0.009). Mean serum MMP-9 level in the SM-exposed group with ocular abnormalities was significantly higher than that in the SM-exposed group without ocular abnormalities. SM-exposed people with corneal calcification had significantly higher serum MMP-9/TIMP-1 level compared to the SM-exposed ones without this problem (P = 0.045), The SM-exposed group with severe ocular injuries had significantly higher MMP-9/TIMP-1 than the controls (P = 0.046). The SM-exposed group had significantly lower levels of MMP-9/TIMP-4 complex than the controls (P < 0.001). The SM-exposed group with tear meniscus and fundus abnormality had significantly higher MMP-9/TIMP-4 levels than the SM-exposed group without these problems (P = 0.009 and P = 0.020). Conclusion: Serum MMP-9 level had increased in SM-exposed groups with ocular problems, while TIMP-1 and TIMP-2 levels had remained unchanged. Serum TIMP-4 drastically decreased in SM-exposed group, which clearly explains the severity of the systemic and ocular damages.

Item Type: Article
Creators:
CreatorsEmail
Ghasemi, H.UNSPECIFIED
Yaraee, R.UNSPECIFIED
Faghihzadeh, S.UNSPECIFIED
Ghassemi-Broumand, M.UNSPECIFIED
Mahmoudi, M.UNSPECIFIED
Babaei, M.UNSPECIFIED
Naderi, M.UNSPECIFIED
Safavi, M.UNSPECIFIED
Ghazanfari, Z.UNSPECIFIED
Rastin, M.UNSPECIFIED
Zamani, S.UNSPECIFIED
Tabasi, N.UNSPECIFIED
Faghihzadeh, E.UNSPECIFIED
Gharebaghi, R.UNSPECIFIED
Hassan, Z. M.UNSPECIFIED
Mirsharif, E. S.UNSPECIFIED
Ghazanfari, T.UNSPECIFIED
Keywords: Sulfur mustard Ocular injury Matrix metalloproteinase-9 (MMP-9) Tissue inhibitors of metalloproteinase-1 (TIMP-1) Tissue inhibitors of metalloproteinase-4 (TIMP-4) matrix metalloproteinases tissue inhibitors dry-eye corneal ulcer cytokines sardasht fluid doxycycline expression pulmonary Immunology Pharmacology & Pharmacy
Divisions:
Page Range: p. 10
Journal or Publication Title: International Immunopharmacology
Journal Index: ISI
Volume: 77
Identification Number: https://doi.org/10.1016/j.intimp.2019.105812
ISSN: 1567-5769
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2689

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