Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Novel green synthesis of Boswellia serrata leaf aqueous extract conjugated gold nanoparticles with excellent anti-acute myeloid leukemia property in comparison to mitoxantrone in a leukemic mice model: Introducing a new chemotherapeutic drug

Fri Jul 1 21:20:47 2022

(2020) Novel green synthesis of Boswellia serrata leaf aqueous extract conjugated gold nanoparticles with excellent anti-acute myeloid leukemia property in comparison to mitoxantrone in a leukemic mice model: Introducing a new chemotherapeutic drug. Applied Organometallic Chemistry. p. 14. ISSN 0268-2605

Full text not available from this repository.

Official URL: http://apps.webofknowledge.com/InboundService.do?F...

Abstract

The present research confirms the capacity of aqueous extract of Boswellia serrata grown under in vitro condition for the green synthesis of gold nanoparticles (AuNPs). Also, we showed the cytotoxicity, antioxidant, and anti-acute myeloid leukemia properties of AuNPs compared to mitoxantrone in a leukemic mouse model. The synthesized AuNPs were characterized using several techniques including XRD, TEM, FE-SEM, UV-Vis, and FT-IR. From the XRD pattern, four distinct diffraction peaks at 38.2 degrees, 44.2 degrees, 64.7 degrees and 77.4 degrees are indexed as (111), (200), (220) and (311) planes of FCC metallic gold. TEM and FE-SEM images revealed an average diameters of 15-30 nm for the nanoparticles. FT-IR findings offered antioxidant compounds in the nanoparticles were the sources of reducing power, reducing gold ions to AuNPs. UV-Vis revealed an absorption band at 536 nm that is related to the surface plasmon resonance of AuNPs. In vivo design, induction of acute myeloid leukemia was done by DMBA in 75 mice. Then, the mice were randomly divided into six subgroups, including untreated, control, HAuCl4, B. serrata, AuNPs, and mitoxantrone. AuNPs (In the dose of 1 mg/kg body weight) similar to mitoxantrone, significantly (p <= 0.05) increased the platelet, lymphocyte, and RBC parameters and the anti-inflammatory cytokines (IL4, IL5, IL10, IL13, and IFN alpha) and reduced the weights and volumes of liver and spleen and their sub-compartment, the total WBC, blast, monocyte, neutrophil, eosinophil, and basophil counts, and the pro-inflammatory cytokines (IL1, IL6, IL12, IL18, IFNY, and TNF alpha) as compared to the untreated mice. By quantitative Real-Time PCR, S1PR1 and S1PR5 mRNA expression in lymphocytes were significantly (p <= 0.05) increased by treating the leukemic mice with the AuNPs and mitoxantrone. In vitro design, AuNPs similar to mitoxantrone had low cell viability dose-dependently against Human HL-60/vcr, 32D-FLT3-ITD, and Murine C1498 cell lines without any cytotoxicity on HUVEC cell line. Besides, the DPPH assay showed similar antioxidant potentials for AuNPs and mitoxantrone. In conclusion, the results of this research indicated the excellent capacity of synthesized gold nanoparticles using B. serrata leaf aqueous extract in the treatment of acute myeloid leukemia in leukemic mice.

Item Type: Article
Creators:
CreatorsEmail
Ahmeda, A.UNSPECIFIED
Zangeneh, M. M.UNSPECIFIED
Keywords: acute myeloid leukemia Boswellia serrata gold nanoparticles leukemic mouse model mitoxantrone antibacterial activity ethanolic extract acid Chemistry
Divisions:
Page Range: p. 14
Journal or Publication Title: Applied Organometallic Chemistry
Journal Index: ISI
Volume: 34
Number: 3
Identification Number: https://doi.org/10.1002/aoc.5344
ISSN: 0268-2605
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2680

Actions (login required)

View Item View Item