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Ilam University of Medical Sciences

Quantifying risks and interventions that have affected the burden of diarrhoea among children younger than 5 years: an analysis of the Global Burden of Disease Study 2017

Sun Jun 26 21:06:43 2022

(2020) Quantifying risks and interventions that have affected the burden of diarrhoea among children younger than 5 years: an analysis of the Global Burden of Disease Study 2017. Lancet Infectious Diseases. pp. 37-59. ISSN 1473-3099

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Abstract

Background Many countries have shown marked declines in diarrhoea! disease mortality among children younger than 5 years. With this analysis, we provide updated results on diarrhoeal disease mortality among children younger than 5 years from the Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) and use the study's comparative risk assessment to quantify trends and effects of risk factors, interventions, and broader sociodemographic development on mortality changes in 195 countries and territories from 1990 to 2017. Methods This analysis for GBD 2017 had three main components. Diarrhoea mortality was modelled using vital registration data, demographic surveillance data, and verbal autopsy data in a predictive, Bayesian, ensemble modelling tool; and the attribution of risk factors and interventions for diarrhoea were modelled in a counterfactual framework that combines modelled population-level prevalence of the exposure to each risk or intervention with the relative risk of diarrhoea given exposure to that factor. We assessed the relative and absolute change in diarrhoea mortality rate between 1990 and 2017, and used the change in risk factor exposure and sociodemographic status to explain differences in the trends of diarrhoea mortality among children younger than 5 years. Findings Diarrhoea was responsible for an estimated 533 768 deaths (95 uncertainty interval 477 162-593 145) among children younger than 5 years globally in 2017, a rate of 78.4 deaths (70.1-87.1) per 100 000 children. The diarrhoea mortality rate ranged between countries by over 685 deaths per 100 000 children. Diarrhoea mortality per 100 000 globally decreased by 69.6 (63.1-74.6) between 1990 and 2017. Among the risk factors considered in this study, those responsible for the largest declines in the diarrhoea mortality rate were reduction in exposure to unsafe sanitation (13.3 decrease, 11.2-15.5), childhood wasting (9.9 decrease, 9.6-10.2), and low use of oral rehydration solution (6.9 decrease, 4-8-8-4). Interpretation Diarrhoea mortality has declined substantially since 1990, although there are variations by country. Improvements in sociodemographic indicators might explain some of these trends, but changes in exposure to risk factors-particularly unsafe sanitation, childhood growth failure, and low use of oral rehydration solution-appear to be related to the relative and absolute rates of decline in diarrhoea mortality. Although the most effective interventions might vary by country or region, identifying and scaling up the interventions aimed at preventing and protecting against diarrhoea that have already reduced diarrhoea mortality could further avert many thousands of deaths due to this illness. Copyright (C) 2019 The Author(s). Published by Elsevier Ltd.

Item Type: Article
Creators:
CreatorsEmail
Troeger, C. E.UNSPECIFIED
Khalil, I. A.UNSPECIFIED
Blacker, B. F.UNSPECIFIED
Biehl, M. H.UNSPECIFIED
Albertson, S. B.UNSPECIFIED
Zimsen, S. R. M.UNSPECIFIED
Rao, P. C.UNSPECIFIED
Abate, D.UNSPECIFIED
Ahmadi, A.UNSPECIFIED
Ahmed, MlcbUNSPECIFIED
Akal, C. G.UNSPECIFIED
Alahdab, F.UNSPECIFIED
Alam, N.UNSPECIFIED
Alene, K. A.UNSPECIFIED
Alipour, V.UNSPECIFIED
Aljunid, S. M.UNSPECIFIED
Al-Raddadi, R. M.UNSPECIFIED
Alvis-Guzman, N.UNSPECIFIED
Amini, S.UNSPECIFIED
Anber, N. H.UNSPECIFIED
Anjomshoa, M.UNSPECIFIED
Antonio, C. A. T.UNSPECIFIED
Arabloo, J.UNSPECIFIED
Aremu, O.UNSPECIFIED
Atalay, H. T.UNSPECIFIED
Atique, S.UNSPECIFIED
Avokpaho, EfgaUNSPECIFIED
Awad, S.UNSPECIFIED
Awasthi, A.UNSPECIFIED
Badawi, A.UNSPECIFIED
Balakrishnan, K.UNSPECIFIED
Banoub, J. A. M.UNSPECIFIED
Barac, A.UNSPECIFIED
Bassat, Q.UNSPECIFIED
Bedi, N.UNSPECIFIED
Bennett, D. A.UNSPECIFIED
Bhattacharyya, K.UNSPECIFIED
Bhutta, Z. A.UNSPECIFIED
Bijani, A.UNSPECIFIED
Car, J.UNSPECIFIED
Carvalho, F.UNSPECIFIED
Castaneda-Orjuela, C. A.UNSPECIFIED
Christopher, D. J.UNSPECIFIED
Dandona, L.UNSPECIFIED
Dandona, R.UNSPECIFIED
Daryani, A.UNSPECIFIED
Demeke, F. M.UNSPECIFIED
Deshpande, A.UNSPECIFIED
Djalalinia, S.UNSPECIFIED
Dubey, M.UNSPECIFIED
Dubljanin, E.UNSPECIFIED
Duken, E. E.UNSPECIFIED
Zaki, M. E.UNSPECIFIED
Endries, A. Y.UNSPECIFIED
Fernandes, E.UNSPECIFIED
Fischer, F.UNSPECIFIED
Fullman, N.UNSPECIFIED
Gardner, W. M.UNSPECIFIED
Geta, B.UNSPECIFIED
Ghadiri, K.UNSPECIFIED
Gorini, G.UNSPECIFIED
Goulart, A. C.UNSPECIFIED
Guo, Y. M.UNSPECIFIED
Hailu, G. B.UNSPECIFIED
Haj-Mirzaian, A.UNSPECIFIED
Haj-Mirzaian, A.UNSPECIFIED
Hamidi, S.UNSPECIFIED
Hassen, H. Y.UNSPECIFIED
Hoang, C. L.UNSPECIFIED
Hostiuc, M.UNSPECIFIED
Hussain, Z.UNSPECIFIED
Irvani, S. S. N.UNSPECIFIED
James, S. L.UNSPECIFIED
Jha, R. P.UNSPECIFIED
Jonas, J. B.UNSPECIFIED
Karch, A.UNSPECIFIED
Kasaeian, A.UNSPECIFIED
Kassa, T. D.UNSPECIFIED
Kassebaum, N. J.UNSPECIFIED
Kefale, A. T.UNSPECIFIED
Khader, Y. S.UNSPECIFIED
Khan, E. A.UNSPECIFIED
Khan, M. N.UNSPECIFIED
Khang, Y. H.UNSPECIFIED
Khoja, A. T.UNSPECIFIED
Kimokoti, R. W.UNSPECIFIED
Kisa, A.UNSPECIFIED
Kisa, S.UNSPECIFIED
Kissoon, N.UNSPECIFIED
Kochhar, S.UNSPECIFIED
Kosen, S.UNSPECIFIED
Koyanagi, A.UNSPECIFIED
Defo, B. K.UNSPECIFIED
Kumar, G. A.UNSPECIFIED
Lal, D. K.UNSPECIFIED
Leshargie, C. T.UNSPECIFIED
Li, S. S.UNSPECIFIED
Lodha, R.UNSPECIFIED
Macarayan, E. R. K.UNSPECIFIED
Majdan, M.UNSPECIFIED
othersUNSPECIFIED
Keywords: nutritional interventions water-quality mortality sanitation africa growth morbidity Infectious Diseases
Divisions:
Page Range: pp. 37-59
Journal or Publication Title: Lancet Infectious Diseases
Journal Index: ISI
Volume: 20
Number: 1
Identification Number: https://doi.org/10.1016/s1473-3099(19)30401-3
ISSN: 1473-3099
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2673

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