Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Decoration of silver nanoparticles on multi-walled carbon nanotubes: Investigation of its anti-acute leukemia property against acute myeloid leukemia and acute T cell leukemia

Sun May 19 23:28:20 2024

(2020) Decoration of silver nanoparticles on multi-walled carbon nanotubes: Investigation of its anti-acute leukemia property against acute myeloid leukemia and acute T cell leukemia. Applied Organometallic Chemistry. p. 10. ISSN 0268-2605

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Abstract

Recently, the development of carbon nanocomposites composed of carbon nanotubes and metal nanoparticles has attracted many interests because of their large potential for technological applications such as catalysts, sensors, biomedicine, and disinfection. In the present study, we described a simple chemistry method to synthesize multi-walled carbon nanotubes (MWCNTs) decorated with silver nanoparticles (Ag-NPs). Also, we investigated the antioxidant and anti-acute leukemia activities against acute myeloid leukemia and acute T cell leukemia cell lines. Ag NPs-MWCNTs were characterized and analyzed using common nanotechnology techniques including transmission electron microscopy (TEM), X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDS), field emission-scanning electron microscopy (FE-SEM) and elemental mapping analysis. Also, 2,2-diphenyl-1-picrylhydrazyl (DPPH) test was performed to assess the antioxidant capacities of AgNO3, MWCNTs, and Ag NPs-MWCNTs. It revealed similar antioxidant potentials for Ag NPs-MWCNTs and butylated hydroxytoluene. In MTT assay, Ag NPs-MWCNTs had very low cell viability (very high anti-acute leukemia properties) dose-dependently against 32D-FLT3-ITD (Acute myeloid leukemia cell line), Human HL-60/vcr (Acute myeloid leukemia cell line), Jurkat, Clone E6-1 (Acute T cell leukemia cell line), and J.RT3-T3.5 (Acute T cell leukemia cell line) without any cytotoxicity on human umbilical vein endothelial cell line (HUVEC; Normal cell line). In conclusion, the synthesized Ag NPs-MWCNTs revealed excellent antioxidant and cytotoxicity activities against acute myeloid leukemia and acute T cell leukemia cell lines in a dose depended manner. After confirming in the in vivo and clinical trials, these nanoparticles can be administrated in humans for the treatment of acute leukemia especially acute myeloid leukemia and acute T cell leukemia.

Item Type: Article
Creators:
CreatorsEmail
Shahriari, M.UNSPECIFIED
Hemmati, S.UNSPECIFIED
Zangeneh, A.UNSPECIFIED
Zangeneh, M. M.UNSPECIFIED
Keywords: acute myeloid leukemia acute t cell leukemia ag nps-mwcnts agno(3) carbon nanotubes iron-oxide nanoparticles green synthesis antibacterial activity recyclable nanocatalyst palladium nanoparticles magnetic nanoparticles catalytic-reduction antioxidant activity oxidative stress ag nanoparticles Chemistry
Divisions:
Page Range: p. 10
Journal or Publication Title: Applied Organometallic Chemistry
Journal Index: ISI
Volume: 34
Number: 4
Identification Number: https://doi.org/10.1002/aoc.5476
ISSN: 0268-2605
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2652

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