Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Chemical characterization and anti-hemolytic anemia potentials of tin nanoparticles synthesized by a green approach for bioremediation applications

Fri Jul 1 21:28:31 2022

(2020) Chemical characterization and anti-hemolytic anemia potentials of tin nanoparticles synthesized by a green approach for bioremediation applications. Applied Organometallic Chemistry. p. 15. ISSN 0268-2605

Full text not available from this repository.

Official URL: http://apps.webofknowledge.com/InboundService.do?F...

Abstract

The therapeutic properties of tin nanoparticles have been proved in recent years. One of their probable effects is anti-anemia. In this study, tin nanoparticles were synthesized and characterized in aqueous medium using Ziziphora clinopodioides Lam leaf aqueous extract as the reducing and stabilizing agent. We also assessed the antihemolytic anemia potential of tin nanoparticles (SnNPs) in an animal model of hemolytic anemia. Tin nanoparticles were characterized using many techniques including Fourier transform-infrared and UV-visible spectroscopy, X-ray diffraction (XRD), energy dispersive X-ray spectrometry, and field emission-scanning electron microscopy (FE-SEM). FE-SEM images showed a uniform spherical morphology in size of 18.12 nm for the green synthesized nanoparticles. According to XRD analysis, SnNPs crystal size was17.94 nm. SnNPs had low cell viability dose-dependently against human umbilical vein endothelial cell line. in vivo design, induction of hemolytic anemia was done by phenylhydrazine in 40 mice. Tin nanoparticles significantly (p <= 0.01) reduced the weight and volume of liver and spleen and the concentration of pro-inflammatory cytokines, and increased the body weight, anti-inflammatory cytokines concentration, total platelet, WBC, neutrophil, lymphocyte, eosinophil, monocyte, and basophil counts, and red blood cell parameters compared to the untreated mice. For the biochemical parameters, SnNPs significantly (p <= 0.01) increased the concentrations of GPx, CAT, and SOD in serum, liver, and spleen and decreased the concentration of GR in serum, liver, and spleen, and also erythropoietin, ferritin, and ferrous in serum as compared to the anemic mice. The 2,2-diphenyl-1-picrylhydrazyl test showed similar antioxidant activities for SnNPs and butylated hydroxytoluene. The results demonstrate the excellent antihemolytic anemia, hematoprotective, cytotoxicity, and antioxidant potentials of SnNPs compared to other experimental groups.

Item Type: Article
Creators:
CreatorsEmail
Ahmeda, A.UNSPECIFIED
Mahdavi, B.UNSPECIFIED
Zaker, F.UNSPECIFIED
Kaviani, S.UNSPECIFIED
Hosseini, S.UNSPECIFIED
Zangeneh, M. M.UNSPECIFIED
Zangeneh, A.UNSPECIFIED
Paydarfar, S.UNSPECIFIED
Moradi, R.UNSPECIFIED
Keywords: antihemolytic anemia leaf tin nanoparticles Ziziphora clinopodioides Lam photocatalytic dye degradation ziziphora-clinopodioides lam. essential oil composition cancer cell-line sno2 nanoparticles antibacterial activity leaf extract antioxidant activity biogenic synthesis ethanolic extract Chemistry
Divisions:
Page Range: p. 15
Journal or Publication Title: Applied Organometallic Chemistry
Journal Index: ISI
Volume: 34
Number: 3
Identification Number: https://doi.org/10.1002/aoc.5433
ISSN: 0268-2605
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2648

Actions (login required)

View Item View Item