Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Chitin binding protein as a possible RNA binding protein in Leishmania parasites

Thu Oct 6 07:49:32 2022

(2020) Chitin binding protein as a possible RNA binding protein in Leishmania parasites. Pathogens and Disease. p. 5. ISSN 2049-632X

Full text not available from this repository.

Official URL: http://apps.webofknowledge.com/InboundService.do?F...

Abstract

Leishmaniasis includes a broad spectrum of pathological outcomes in humans caused by protozoan parasites from the genus Leishmania. In recent years, proteomic techniques have introduced novel proteins with critical functions in Leishmania parasites. Based on our report of a Chitin binding protein (CBP) in our previous immunoproteomic study, this article suggests that CBP might be an RNA binding protein (RBP) in Leishmania parasites. RBPs, as key regulatory factors, have a role in post-transcriptional gene regulation. The presence of RBPs in Leishmania parasites has not been considered so far; however, this study aims to open a new venue regarding RBPs in Leishmania parasites. Confirming CBP as an RBP in Leishmania parasites, exploring other RBPs and their functions might lead to interesting issues in leishmaniasis. In fact, due to the regulatory role of RBPs in different diseases including cancers and their further classification as therapeutic targets, the emerging evaluation of CBP and RBPs from Leishmania parasites may allow the discovery of novel and effective drugs against leishmaniasis.

Item Type: Article
Creators:
CreatorsEmail
Rashidi, S.UNSPECIFIED
Kalantar, K.UNSPECIFIED
Fernandez-Rubio, C.UNSPECIFIED
Anvari, E.UNSPECIFIED
Nguewa, P.UNSPECIFIED
Hatam, G.UNSPECIFIED
Keywords: Leishmania chitin binding protein RNA binding protein therapeutic target gene-expression genome coordination encodes family Immunology Infectious Diseases Microbiology
Divisions:
Page Range: p. 5
Journal or Publication Title: Pathogens and Disease
Journal Index: ISI
Volume: 78
Number: 1
Identification Number: https://doi.org/10.1093/femspd/ftaa007
ISSN: 2049-632X
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2630

Actions (login required)

View Item View Item