Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Introducing a novel chemotherapeutic drug formulated by iron nanoparticles for the clinical trial studies

Thu Dec 1 17:09:13 2022

(2020) Introducing a novel chemotherapeutic drug formulated by iron nanoparticles for the clinical trial studies. Applied Organometallic Chemistry. p. 10. ISSN 0268-2605

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Abstract

In recent years, the experiments have revealed that plants raise the cytotoxicity and anticancer potentials of iron nanoparticles against several cell lines especially tumor cell lines. In the present study, we formulated a modern drug by iron nanoparticles (FeNPs) containing Glycyrrhiza glabra L leaf for the treatment of acute lymphoblastic leukemia. Characterization of FeNPs was done by TEM, FE-SEM, UV-Vis, and FT-IR. FE-SEM and TEM images revealed an average diameter of 11-18 nm for the nanoparticles. UV-Vis revealed an absorption band at 298 nm that is related to the surface plasmon resonance of FeNPs. FT-IR results offered antioxidant compounds in the nanoparticles were the sources of reducing power, reducing iron ions to FeNPs. MTT assay was used on normal (HUVEC) and acute lymphoblastic leukemia (MOLT-3, CEM/C2, TALL-104, and CCRF-CEM) cell lines for comparing the anti-acute lymphoblastic leukemia properties of FeCl3, G. glabra, and FeNPs. Iron nanoparticles had very low cell viability dose-dependently against MOLT-3, CEM/C2, TALL-104, CCRF-CEM cell lines without any cytotoxicity on the HUVEC cell line. The best result of cytotoxicity property of FeNPs against the above cell lines was seen in the case of CCRF-CEM cell line. These nanoparticles can be administrated in humans for the treatment of acute lymphoblastic leukemia after confirming in the in vivo and clinical trials.

Item Type: Article
Creators:
CreatorsEmail
Ma, L.UNSPECIFIED
Ahmeda, A.UNSPECIFIED
Wang, K. F.UNSPECIFIED
Jalalvand, A. R.UNSPECIFIED
Sadrjavadi, K.UNSPECIFIED
Nowrozi, M.UNSPECIFIED
Zangeneh, A.UNSPECIFIED
Zangeneh, M. M.UNSPECIFIED
Wang, X. J.UNSPECIFIED
Keywords: acute lymphoblastic leukemia Glycyrrhiza glabra L leaf in vitro condition iron nanoparticles saralicum rm fritsch ethanolic extract glycyrrhiza-glabra aqueous extract tea extract green antibacterial degradation antioxidant toxicity Chemistry
Divisions:
Page Range: p. 10
Journal or Publication Title: Applied Organometallic Chemistry
Journal Index: ISI
Identification Number: https://doi.org/10.1002/aoc.5498
ISSN: 0268-2605
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2621

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