Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Alteration in serum levels of immunoglobulins in seriously eye-injured long-term following sulfur-mustard exposure

Mon Jun 27 10:03:28 2022

(2020) Alteration in serum levels of immunoglobulins in seriously eye-injured long-term following sulfur-mustard exposure. International Immunopharmacology. p. 9. ISSN 1567-5769

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Abstract

Introduction: Sulfur mustard (SM) is a potent toxic agent that cause local and systemic changes in the human body such as dysregulation of the immunological system. This gas affects different organs such as lungs, skin, eyes and the gastrointestinal tract. Methods: 128 veterans with SM-induced eye injuries were examined and compared to 31 gender- and age-matched healthy controls. Serum levels of IgM, IgE, IgA, IgG, and IgG subclasses were measured using ELISA method. Results: There was no significant difference in IgM level between two groups with abnormal and normal ocular conditions except for those having bulbar conjunctiva-limbal ischemia and bulbar conjunctiva-hyperemia abnormalities. There were not significant difference in IgA, IgE, and IgG levels between two groups with and without ocular problem also between study groups. IgG1 level in some ocular abnormalities were significantly lower than the healthy control-groups. IgG2 level in SM-exposed participants with stromal abnormality was higher in the SM-exposed groups without this problem. IgG2 levels in the exposed group with some ocular problems were significantly increased compared with control. IgG3 level in all patients did not reveal any significant changes compared with the controls except the fundus abnormality. IgG4 level was not significantly different between two groups with normal and abnormal ocular conditions. Nonetheless, IgG4 level in the exposed participants with some ocular abnormalities significantly increased compared with the controls. Conclusion: The results showed SM exposure could alter immunoglobulins level compared with healthy controls and the changes of IgG2 and IgG1 levels were associated with some ocular problems.

Item Type: Article
Creators:
CreatorsEmail
Ghazanfari, T.UNSPECIFIED
Mostafaie, A.UNSPECIFIED
Talebi, F.UNSPECIFIED
Mandavi, M. R. V.UNSPECIFIED
Yarmohammadi, M. E.UNSPECIFIED
Askari, N.UNSPECIFIED
Moaiedmohseni, S.UNSPECIFIED
Majd, A. M. M.UNSPECIFIED
Mirsharif, E. S.UNSPECIFIED
Ghazanfari, Z.UNSPECIFIED
Hassan, Z. M.UNSPECIFIED
Shams, J.UNSPECIFIED
Jamali, D.UNSPECIFIED
Faghihzadeh, S.UNSPECIFIED
Keywords: Sulfur mustard Ocular abnormality Immunoglobulin complications sardasht pulmonary therapy Immunology Pharmacology & Pharmacy
Divisions:
Page Range: p. 9
Journal or Publication Title: International Immunopharmacology
Journal Index: ISI
Volume: 80
Identification Number: https://doi.org/10.1016/j.intimp.2019.105895
ISSN: 1567-5769
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2614

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