Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Mitochondrial dysfunction in age-related macular degeneration: melatonin as a potential treatment

Wed May 22 12:38:33 2024

(2020) Mitochondrial dysfunction in age-related macular degeneration: melatonin as a potential treatment. Expert Opinion on Therapeutic Targets. pp. 359-378. ISSN 1472-8222

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Abstract

Introduction: Age-related Macular Degeneration (AMD), a retinal neurodegenerative disease is the most common cause of blindness among the elderly in developed countries. The impairment of mitochondrial biogenesis has been reported in human retinal pigment epithelium (RPE) cells affected by AMD. Oxidative/nitrosative stress plays an important role in AMD development. The mitochondrial respiratory system is considered a major site of reactive oxygen species (ROS) generation. During aging, insufficient free radical scavenger systems, impairment of DNA repair mechanisms and reduction of mitochondrial degradation and turnover contribute to the massive accumulation of ROS disrupting mitochondrial function. Impaired mitochondrial function leads to the decline in the autophagic capacity and induction of inflammation and apoptosis in human RPE cells affected by AMD. Areas covered: This article evaluates the ameliorative effect of melatonin on AMD and examines AMD pathogenesis with an emphasis on mitochondrial dysfunction. It also considers the potential effects of melatonin on mitochondrial function. Expert opinion: The effect of melatonin on mitochondrial function results in the reduction of oxidative stress, inflammation and apoptosis in the retina; these findings demonstrate that melatonin has the potential to prevent and treat AMD.

Item Type: Article
Creators:
CreatorsEmail
Mehrzadi, S.UNSPECIFIED
Hemati, K.UNSPECIFIED
Reiter, R. J.UNSPECIFIED
Hosseinzadeh, A.UNSPECIFIED
Keywords: Age-related macular degeneration melatonin mitochondria oxidative stress autophagy apoptosis complement factor-h retinal-pigment epithelium nitric-oxide synthase induced oxidative stress early brain-injury induced apoptosis DNA damage cell-death inflammatory cytokines serotonin-transferase Pharmacology & Pharmacy
Divisions:
Page Range: pp. 359-378
Journal or Publication Title: Expert Opinion on Therapeutic Targets
Journal Index: ISI
Volume: 24
Number: 4
Identification Number: https://doi.org/10.1080/14728222.2020.1737015
ISSN: 1472-8222
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2608

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