Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The Therapeutic Potential of Conditioned Medium from Human Breast Milk Stem Cells in Treating Spinal Cord Injury

Sun Mar 26 19:43:38 2023

(2020) The Therapeutic Potential of Conditioned Medium from Human Breast Milk Stem Cells in Treating Spinal Cord Injury. Asian Spine Journal. pp. 131-138. ISSN 1976-1902

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Abstract

Study Design: Experimental animal study. Purpose: This study investigated the therapeutic effects of human breast milk stern cell (BMSC)-conditioned medium (BMSC-CM) in a model of spinal cord injury (SCI) in male Sprague-Dawley rats. Overview of Literature: SCI is one of the leading causes of disability in addition to sensory and motor impairment. So far, there have been no successful treatments for SCI. Given the positive outcomes associated with using stem cells and their derivatives as a treatment for various diseases, there is a growing interest in using them as an SCI treatment. Recent research has demonstrated that CM from stern cells has therapeutic advantages. Methods: Human BMSCs were isolated and characterized, and CM was subsequently collected. Animals received an intrathecal administration of BMSC-CM after SCI. The activity of caspase-3 was measured to assess apoptosis, and levels of tumor necrosis factor-a and interleukin-1 beta were measured to assess inflammation. Also, sensory and locomotor performances were assessed after SCI and BMSC-CM administration. Results: Administration of CM from BMSC reduced apoptosis and inflammation at the site of injury in a rat model of SCI (p<0.05). Motor, sensory, locomotor, and sensorimotor performances were significantly improved in rats that received BMSC-CM after SCI. Conclusions: Intrathecal administration of BMSC-CM improved recovery in a rat model of SCI.

Item Type: Article
Creators:
CreatorsEmail
Borhani-Haghighi, M.UNSPECIFIED
Navid, S.UNSPECIFIED
Mohamadi, Y.UNSPECIFIED
Keywords: Conditioned media Spinal cord injuries Breast milk Stem cells functional recovery inflammation Orthopedics
Divisions:
Page Range: pp. 131-138
Journal or Publication Title: Asian Spine Journal
Journal Index: ISI
Volume: 14
Number: 2
Identification Number: https://doi.org/10.31516/asj.2019.0026
ISSN: 1976-1902
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2602

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