Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Prolonged Persistence of Chimeric Antigen Receptor (CAR) T Cell in Adoptive Cancer Immunotherapy: Challenges and Ways Forward

Mon Nov 28 15:18:43 2022

(2020) Prolonged Persistence of Chimeric Antigen Receptor (CAR) T Cell in Adoptive Cancer Immunotherapy: Challenges and Ways Forward. Frontiers in Immunology. p. 17. ISSN 1664-3224

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Abstract

CAR T cell qualities, such as persistence and functionality play important roles in determining the outcome of cancer immunotherapy. In spite of full functionality, it has been shown that poor persistence of CAR T cells can limit an effective antitumor immune response. Here, we outline specific strategies that can be employed to overcome intrinsic and extrinsic barriers to CAR T cell persistence. We also offer our viewpoint on how growing use of CAR T cells in various cancers may require modifications in the intrinsic and extrinsic survival signals of CAR T cells. We anticipate these amendments will additionally provide the rationales for generation of more persistent, and thereby, more effective CAR T cell treatments. CAR T cell qualities, such as persistence and functionality play important roles in determining the outcome of cancer immunotherapy. In spite of full functionality, it has been shown that poor persistence of CAR T cells can limit an effective antitumor immune response. Here, we outline specific strategies that can be employed to overcome intrinsic and extrinsic barriers to CAR T cell persistence. We also offer our viewpoint on how growing use of CAR T cells in various cancers may require modifications in the intrinsic and extrinsic survival signals of CAR T cells. We anticipate these amendments will additionally provide the rationales for generation of more persistent, and thereby, more effective CAR T cell treatments.

Item Type: Article
Creators:
CreatorsEmail
Jafarzadeh, L.UNSPECIFIED
Masoumi, E.UNSPECIFIED
Fallah-Mehrjardi, K.UNSPECIFIED
Mirzaei, H. R.UNSPECIFIED
Hadjati, J.UNSPECIFIED
Keywords: chimeric antigen receptor T cells persistence tumor microenvironment cancer immunotherapy in-vivo persistence dose recombinant interleukin-2 memory stem-cells antitumor-activity oxidative stress b-cell phase-i metastatic melanoma apoptotic proteins telomere length Immunology
Divisions:
Page Range: p. 17
Journal or Publication Title: Frontiers in Immunology
Journal Index: ISI
Volume: 11
Identification Number: https://doi.org/10.3389/fimmu.2020.00702
ISSN: 1664-3224
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2587

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