Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Environmental exposure to nonylphenol and cancer progression Risk-A systematic review

Wed May 22 10:54:36 2024

(2020) Environmental exposure to nonylphenol and cancer progression Risk-A systematic review. Environmental Research. p. 12. ISSN 0013-9351

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Environmental exposure to nonylphenol (NP) can adversely affect human and wildlife health. A systematic review was conducted to evaluate the relationship between environmental NP exposure and cancer progression risk. Literature surveys were conducted within several international databases using appropriate keywords. A comprehensive search yielded 58 eligible studies involving a wide range of adverse effects, exposure assessment methods, study designs, and experimental models. Most studies reported that NP strongly induced breast cancer progression in intended experiments. Positive associations between NP exposure and ovarian, uterine, pituitary, and testicular cancers were also reported. Although some studies reported no relation between environmental NP exposure and tumour and/or cancer progression, NP (a known endocrine disrupting chemical) induced action mechanisms in multiple experimental models and may interfere with/hyper-activate oestrogen signalling. Secretion of oestrogen and development of reproductive tissues like breasts, uteruses, and ovaries showed strong associations with possible neoplasia (i.e., uncontrolled development of tumours and/or malignant cancers). Findings of this study are important for informing policymakers to pass legislation limiting the use of environmental contaminants such as NP before all adverse effects of exposure have been determined.

Item Type: Article
Noorimotlagh, Z.UNSPECIFIED
Hoseinzadeh, M.UNSPECIFIED
Jaafarzadeh, N.UNSPECIFIED
Keywords: Nonylphenol Tumour development Malignant cancer Oestrogenic activity Endocrine disrupting chemical Oestrogen signalling estrogen-receptor-alpha epithelial-mesenchymal transition breast-cancer bisphenol-a in-vivo cell-growth alkylphenolic compounds luciferase reporter androgen receptor down-regulation Environmental Sciences & Ecology Public, Environmental & Occupational Health
Page Range: p. 12
Journal or Publication Title: Environmental Research
Journal Index: ISI
Volume: 184
Identification Number:
ISSN: 0013-9351
Depositing User: مهندس مهدی شریفی

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