Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

A glassy carbon electrode modified with carbon nanoonions for electrochemical determination of fentanyl

Tue Dec 6 04:24:25 2022

(2020) A glassy carbon electrode modified with carbon nanoonions for electrochemical determination of fentanyl. Materials Science & Engineering C-Materials for Biological Applications. p. 10. ISSN 0928-4931

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Abstract

Fentanyl is a pain reliever stronger and deadlier than heroin. This lethal drug has killed many people in different countries recently. Due to the importance of the diagnosis of this drug, a fentanyl electrochemical sensor is developed based on a glassy carbon electrode (GCE) modified with the carbon nanoonions (CNOs) in this study. Accordingly, the electrochemical studies indicated the sensor is capable of the voltammetric determination of traces of fentanyl at a working potential of 0.85 (vs. Ag/AgCl). To obtain the great efficiency of the sensor some experimental factors such as time, the potential of accumulation and pH value of the electrolyte were optimized. The results illustrated a reduction and two oxidation peaks for fentanyl in phosphate buffer (PB) with pH = 7.0 under a probable mechanism of electrochemical-chemical-electrochemical (ECE). The differential pulse voltammetry (DPV) currents related to the fentanyl detection were linear with an increase of fentanyl concentrations in a linear range between 1 mu M to 60 mu M with a detection limit (LOD) of 300 nM. Furthermore, the values of the diffusion coefficient (D), transfer coefficient (alpha) and catalytic constant rate (k(cat)) were calculated to be 2.76 x 10(-6) cm(2) s(-1), 0.54 and 1.76 x 10(4) M-1 s(-1), respectively. These satisfactory results may be attributed to utilizing the CNOs in the electrode modification process due to some of its admirable characterizations of this nanostructure including high surface area, excellent electrical conductivity and good electrocatalytic activity. Consequently, these finding points the achieving a simple sensing system to measure of the fentanyl as an important drug from the judicial perspective might be a dream coming true soon.

Item Type: Article
Creators:
CreatorsEmail
Sohouli, E.UNSPECIFIED
Keihan, A. H.UNSPECIFIED
Shahdost-fard, F.UNSPECIFIED
Naghian, E.UNSPECIFIED
Plonska-Brzezinska, M. E.UNSPECIFIED
Rahimi-Nasrabadi, M.UNSPECIFIED
Ahmadi, F.UNSPECIFIED
Keywords: Fentanyl Carbon nanoonion Electrochemistry Glassy carbon electrode nitride quantum dots nano-onions gas-chromatography plasma sensor functionalization nanoparticles norfentanyl performance metabolites Materials Science
Divisions:
Page Range: p. 10
Journal or Publication Title: Materials Science & Engineering C-Materials for Biological Applications
Journal Index: ISI
Volume: 110
Identification Number: https://doi.org/10.1016/j.msec.2020.110684
ISSN: 0928-4931
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2583

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