Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The Association between lasB and nanI Genes with Biofilm Formation in Pseudomonas aeruginosa Clinical Isolates

Wed Sep 28 14:17:59 2022

(2020) The Association between lasB and nanI Genes with Biofilm Formation in Pseudomonas aeruginosa Clinical Isolates. Journal of Clinical and Diagnostic Research. DC01-DC03. ISSN 2249-782X

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Abstract

Introduction: Several acute and chronic infections in humans can be caused by Pseudomonas aeruginosa (P.aeruginosa). Biofilm formation by these bacteria threatens health setting via increasing resistance against antimicrobial agents. Aim: To investigate the association between lasB and nanI genes with biofilm formation in P. aeruginosa clinical isolates. Materials and Methods: A total of 161 P. aeruginosa clinical isolates were collected. The Microtiter Plate (MTP) method was applied for biofilm formation assay. Gene amplification was conducted by PCR method with specific primers. Results: Present study findings showed that the prevalence of lasB and the nanI were 80.7 (130/161) and 24.8 (40/161), respectively. The biofilm formation results demonstrated that 15.5 (25/161) of isolates were not able to produce biofilm. It was considerable that the prevalence of lasB in P. aeruginosa producing biofilm was higher. Conclusion: lasB can be considered as an effective factor for biofilm formation in P. aeruginosa isolates.

Item Type: Article
Creators:
CreatorsEmail
Mahdavi, Z.UNSPECIFIED
Hemati, S.UNSPECIFIED
Sadeghifard, N.UNSPECIFIED
Jalilian, F. A.UNSPECIFIED
Taherikalani, M.UNSPECIFIED
Bimanand, L.UNSPECIFIED
Pakzad, I.UNSPECIFIED
Ghafourian, S.UNSPECIFIED
Keywords: Elastase B Neuraminidase Quorum sensing cystic-fibrosis virulence genes neuraminidase secretion infection features General & Internal Medicine
Divisions:
Page Range: DC01-DC03
Journal or Publication Title: Journal of Clinical and Diagnostic Research
Journal Index: ISI
Volume: 14
Number: 5
Identification Number: https://doi.org/10.7860/jcdr/2020/16076.13697
ISSN: 2249-782X
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2577

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