Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The relationship between metabolic syndrome and increased risk of Barrett's esophagus: an updated systematic review and meta-analysis

Wed Feb 28 23:03:25 2024

(2020) The relationship between metabolic syndrome and increased risk of Barrett's esophagus: an updated systematic review and meta-analysis. Bmc Gastroenterology. p. 9.

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Abstract

BackgroundThe relationship between metabolic syndrome (MetS) and Barrett's esophagus (BE) is still a challenging issue, and inconsistent results have been reported in different studies. Therefore, this study was conducted to determine the relationship between MetS and BE.MethodsIn this study, we followed the MOOSE protocol and results were reported according to the PRISMA guidelines. All study steps were performed independently by two authors. If necessary, the dispute was resolved by consultation with a third author. The search strategy is designed to find published studies. Comprehensive search was done in the following databases until July 2019: Cochrane Library, PubMed/Medline, Web of Science, Science Direct, EMBASE, Scopus, CINAHL, EBSCO, and Google Scholar search engine. All analyses were performed using Comprehensive Meta-Analysis Software Ver.2, while p-value lower than 0.05 was considered significant.ResultsIn 14 studies with a sample size of 108,416, MetS significantly increased the risk of BE (OR=1.354; 95 CI: 1.145-1.600; P<0.001; Heterogeneity: I-2 =81.95; P<0.001). Sensitivity analysis by omitting one study showed that overall estimates are still robust. Subgroup analysis was significant for continent (P<0.001) and MetS diagnostic criteria (P=0.043), but was not significant for variables of study type (P=0.899), study setting (P=0.115), control groups (P=0.671) and quality of studies (P=0.603). The Begg (P=0.912) and Egger's (P=0.094) tests were not significant; therefore, the publication bias did not play a role in the results.ConclusionMetS increases the risk of BE compared to control groups. The results of this study can help health practitioners by identifying a treatable risk factor for the most important risk factor for esophageal carcinoma (ie, BE). Future studies should examine whether treatment for MetS reduces the risk of BE.

Item Type: Article
Creators:
CreatorsEmail
Karimian, M.UNSPECIFIED
Salamati, M.UNSPECIFIED
Azami, M.UNSPECIFIED
Keywords: Metabolic syndrome Barrett's esophagus Meta-analysis helicobacter-pylori infection central adiposity reflux esophagitis association adenocarcinoma epidemiology prevalence obesity Gastroenterology & Hepatology
Divisions:
Page Range: p. 9
Journal or Publication Title: Bmc Gastroenterology
Journal Index: ISI
Volume: 20
Number: 1
Identification Number: https://doi.org/10.1186/s12876-020-01267-2
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2576

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